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Table 3 Frequency of genotypes of Pfdhfr and Pfdhps among the AS/SP and DAPPQ groups P. falciparum isolates from Southeastern Sudan

From: Assessment of Plasmodium falciparum drug resistance molecular markers from the Blue Nile State, Southeast Sudan

Drug resistance markerNumber of mutationsMutation haplotypeDAPPQ
n = 55
AS/SP
n = 49
Total (n 104) n (%)
dhfrNoneWild type NCSI3 (5.45%)0 (0%)3 (2.9%)
DoubleICNI40 (72.7%)32 (65.3%)72 (69.2%)
NRNI1 (1.8%)6 (12.2%)7 (6.7%)
TripleIRNI11 (20%)11 (22.4%)22 (21.1%)
dhpsNoneWild type SAKAA11(20%)3 (6.1)14 (13.5%)
SingleAAKAA4 (7.3%)0 (0%)4 (3.8%)
SGKAA4 (7.3%)3 (6.1)7 (6.7%)
DoubleSGEAA15 (27.3)17 (34.7%)32 (30.7%)
TripleSGEGA21 (38.1)24 (48.9%)45 (43.2%)
AGEAA0 (0%)1 (2%)1 (0.96%)
SGEAT0 (0%)1 (2%)1 (0.96%)
dhfr + dhpsNoneWild type NCSI + SAKAA1 (1.8%)0 (0%)1 (0.96%)
SingleNCSI + AAKAA2 (3.6%)0 (0%)2 (1.9%)
DoubleICNI +SAKAA8 (14.5%)3 (6.1%)11 (10.6%)
TripleIRNI +SAKAA2 (3.6%)0 (0%)2 (1.9%)
ICNI + AAKAA3 (5.45%)0 (0%)3 (2.9%)
ICNI + SGKAA0 (0%)2 (4%)2 (1.9%)
NRNI + SGKAA1 (1.8%)1 (2%)2 (1.9%)
QuadrupleIRNI + SGKAA2 (3.6%)0 (0%)2 (1.9%)
ICNI + SGEAA14 (25.5%)9 (18.4%)23 (22.1%)
NRNI + SGEAA0 (0%)1 (2%)1 (0.96%)
QuintupleIRNI + SGEAA1 (1.8%)7 (14.3%)8 (7.7%)
ICNI + AGEAA0 (0%)1 (2%)1 (0.96%)
ICNI + SGEGA15 (27.3)16 (32.6%)31 (29.8%)
ICNI + SGEAT0 (0%)1 (2%)1 (0.96%)
NRNI I + SGEGA0 (0%)4 (8.1%)4 (3.8%)
HextupleIRNI + SGEGA6 (10.9%)4 (8.1%)10 (9.6%)