Metabolic alterations in the erythrocyte during blood-stage development of the malaria parasite

Malaria Journal

Table 1 Metabolomic data obtained from blood-stage parasites

N_metabolites	N_time	n^a	Source of data	Year	References
Obtained at multiple time points from uninfected and infected erythrocytes
104	7	3	Uninfected and parasite-infected synchronous cultures of erythrocytes	2009	[4]
120	10	2	Uninfected and parasite-infected synchronous cultures of erythrocytes	2012	[8]
501	6	4	Uninfected and parasite-infected synchronous cultures of erythrocytes	–	This study
Other relevant data obtained during the IDC
52	1	13	Saponin-treated synchronous parasite culture	2009	[16]
104	1	4	Uninfected and parasite-infected asynchronous cultures of erythrocytes (absence/presence of streptolysin O)	2013	[20]
76	5^b	6	Parasite-infected synchronous cultures of erythrocytes	2016	[21]
113	1	3	Parasite-infected synchronous cultures of erythrocytes	2016	[22]
460	1	4	Parasite-infected synchronous cultures of erythrocytes	2016	[6]
583	1	3^c	Uninfected and parasite-infected synchronous cultures of erythrocytes	2017	[23]
297	1	5	Saponin-treated synchronous parasite culture	2018	[24]

N_metabolites number of metabolites quantified, N_time number of time points sampled during the intraerythrocytic developmental cycle (IDC)
^aNumber of replicates at each time point
^bTime points cover the first 6 h after treatment by a drug
^cData from uninfected erythrocytes do not have a replicate

ISSN: 1475-2875