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Fig. 6 | Malaria Journal

Fig. 6

From: Characterization of two in vivo challenge models to measure functional activity of monoclonal antibodies to Plasmodium falciparum circumsporozoite protein

Fig. 6

Power to detect differences in protection measured by the protection from parasitaemia assay comparing a candidate mAb to AB311 (43% protective) at a single dose (300 µg) by varying sample sizes. Candidate mAbs were varied by increasing potency interpreted as either the fold reduction in ID50 (bottom axis) or the absolute protection at 300 ug (top axis). Fold reduction in ID50 and protection at 300 ug are related through the dose–response relationships fit to AB311 and AB317 (2PL models). The vertical dashed line represents the estimated fold reduction in ID50 between AB317 and AB311 (1.45-fold) and 78% protection for AB317 at 300 µg

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Malaria Journal

ISSN: 1475-2875

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