Characterization of two in vivo challenge models to measure functional activity of monoclonal antibodies to Plasmodium falciparum circumsporozoite protein

Table 1 Assay consistency across studies

Dose (µg)	Log 10 flux values for studies 1 to 7 using specified mAb
	1—AB311		2—AB311		3—AB311		4—AB311		4—AB1245		5—AB311		6—AB311		7—AB311
	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD
600	Not applicable (N/A)						5.38	0.05	7.40	0.11	5.31	0.26	5.40	0.13	5.31	0.05
300	5.83	0.24	5.84	0.22	5.84	0.25	5.56	0.17	7.43	0.16	5.82	0.18	5.77	0.10	5.58	0.17
100	6.41	0.20	6.57	0.17	6.53	0.35	6.46	0.21	7.32	0.08	6.01	0.21	6.25	0.23	6.16	0.15
30	7.06	0.11	7.05	0.12	N/A		7.03	0.11	7.47	0.06	6.84	0.12	6.52	0.15	6.64	0.16
10											6.95	0.12
Untreated	7.62	0.06	7.48	0.05	7.46	0.08	7.47	0.15	7.47	0.15	7.22	0.10	7.25	0.06	7.20	0.15
Naïve	5.09	0.09	5.11	0.03	5.03	0.18	5.08	0.13	5.07	0.12	5.24	0.03	5.25	0.02	5.25	0.03

Studies 1, 2, 3 did not include a 600-µg group. Only study five had a 10-µg group. Individual mouse total flux values were used to calculate geometric mean for each dose group
mAb monoclonal antibody, SD standard deviation as estimated using a random effects model as described in methods

ISSN: 1475-2875