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Table 4 Comparison of ID50 for AB311 and AB317 in protection from parasitaemia assay

From: Characterization of two in vivo challenge models to measure functional activity of monoclonal antibodies to Plasmodium falciparum circumsporozoite protein

Study

AB311 (μg)

AB317 (μg)

Ratio

P value

1

341 (228, 455)

205 (119, 290)

1.7

0.07

2

304 (239, 369)

170 (*)

1.8

0.46

3

305 (229, 381)

295 (221, 368)

1.0

0.44

Pooled

320 (270, 371)

227 (178, 277)

1.4

0.02

  1. ID50 was estimated in three studies and a pooled group with data from all three studies using 2PL analysis. * 2PL method could not estimate confidence intervals for this experiment
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Malaria Journal

ISSN: 1475-2875

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