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Fig. 6 | Malaria Journal

Fig. 6

From: Immunization with virus-like particles conjugated to CIDRα1 domain of Plasmodium falciparum erythrocyte membrane protein 1 induces inhibitory antibodies

Fig. 6

Sequence analysis of CIDRα1 domains. a Pairwise sequence similarity (19 kDa sequences) of the assayed CIDRα1 domains to HB3var03 CIDRα1.4. Blue (immunogen variant) and red asterisks (*) mark CIDRα1 domain variants inhibited > 40%. b Maximum likelihood tree (key bootstrap [N = 50] values are indicated on branches) of 885 CIDRα1 sequences (30 kDa) (generated in [26]). The 34 CIDRα1 variants tested for EPCR-binding inhibition (marked with boxes) are red if inhibited > 40% by total purified IgG from animals immunized with VLP-catCIDRα1.4 or for the cognate immunogen, blue. CIDRα1 variants not inhibited are green

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Malaria Journal

ISSN: 1475-2875

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