Table 2 Results of ART and LUM APIs solubility in different media as determined by HPLC
# | Medium | Solubility (µg/ml) |
|---|---|---|
ART | ||
1 | 0.5% w/v Myrj 52/HCl (pH 1.2) | 151 |
2 | 1% w/v Myrj 52/HCl (pH 1.2) | 181 |
3 | 1% w/v Myrj 52/HCl (pH 2.3) | 290 |
4 | 1.5% w/v Myrj 52/HCl (pH 2.3) | 452 |
5 | 2% w/v Myrj 52/HCl (pH 2.3) | 652 |
6 | 0.5% w/v SLS/HCl (pH 1.2) | 323 |
7 | 1% w/v SLS/HCl (pH 1.2) | 337 |
8 | 0.5% w/v Myrj 52/0.05Â M ammonium acetate buffer (pH 4.5) | 8 |
9 | 1% w/v Myrj 52/0.05Â M ammonium acetate buffer (pH 4.5) | 33 |
10 | 0.5% w/v SLS/0.05Â M ammonium acetate buffer (pH 4.5) | 138 |
11 | 1% w/v SLS/0.05Â M ammonium acetate buffer (pH 4.5) | 219 |
12 | 0.5% w/v Myrj 52/0.05Â M sodium phosphate buffer (pH 6.8) | 22 |
13 | 1% w/v Myrj 52/0.05Â M sodium phosphate buffer (pH 6.8) | 37 |
14 | 0.5% w/v SLS/0.05 sodium phosphate buffer (pH 6.8) | 5 |
15 | 1% w/v SLS/0.05Â M sodium phosphate buffer (pH 6.8) | 5 |
16 | 0.5% w/v Tween80/0 0.05Â M ammonium acetate buffer (pH 4.5) | 24 |
17 | 1% w/v Tween 80/0.05Â M ammonium acetate buffer (pH 4.5) | 23 |
18 | 0.5% w/v Tween 80/HCl (pH 1.2) | 10 |
19 | 1% w/v Tween 80/HCl (pH 1.2) | 17 |
LUM | ||
20 | 1% w/v Myrj 52/HCl (pH 2.3) | 626 |
21 | 1.5% w/v Myrj 52/HCl (pH 2.3) | 813 |
22 | 2% w/v Myrj 52/HCl (pH 2.3) | 1033 |
23 | 1% w/v Tween 80/HCl (pH 1.2) | 112 |
24 | 1% w/v Benzalkonium chloride/HCl (pH 1.2) | 93 |
25 | 1% w/v Sodium lauryl sulfate/HCl (pH 1.2) | 59 |