First trimester use of artemisinin-based combination therapy and the risk of low birth weight and small for gestational age

Table 3 Adjusted associations for mean weight at birth

	Mean difference in g (95% CI)
	Unadjusted^a	p-value	Adjusted^b	p-value
Birth weights measured within 24 h of birth (N)	1543		1533
No exposure	0 (reference)		0 (reference)
Artemisinin	37.8 (− 67.7; 143.3)	0.482	29.6 (− 62.0; 121.3)	0.526
Quinine	− 32.1 (− 207.9; 143.8)	0.721	− 29.0 (− 181.6; 123.6)	0.709
Birth weights measured within 7 days of birth (N)	1915		1905
No exposure	0 (reference)		0 (reference)
Artemisinin	34.9 (− 62.7; 132.5)	0.483	40.0 (− 47.8; 127.8)	0.371
Quinine	− 4.2 (− 185.7; 177.2)	0.964	− 3.6 (− 166.8; 159.6)	0.965
Quinine vs artemisinin (N)	118		118
Artemisinin	0 (reference)		0 (reference)
Quinine	− 108.0 (− 341.2; 125.1)	0.361	− 167.7 (− 391.6; 56.1)	0.140

^aUnadjusted regression includes dummy indicators for site
^bAdjusted for site, age at recruitment, gravidity, marital status and education level

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