The potential of anti-malarial compounds derived from African medicinal plants: a review of pharmacological evaluations from 2013 to 2019

Bekono, Boris D.; Ntie-Kang, Fidele; Onguéné, Pascal Amoa; Lifongo, Lydia L.; Sippl, Wolfgang; Fester, Karin; Owono, Luc C. O.

doi:10.1186/s12936-020-03231-7

Table 1 Summary of testing methodologies and parasite strains described in this report

From: The potential of anti-malarial compounds derived from African medicinal plants: a review of pharmacological evaluations from 2013 to 2019

Murine (in vivo) models	Strains	Parasite name	Origin	Assay description	References
CQ-sensitive	NK 173	Plasmodium berghei	Not reported	Not reported
	ANKA	P. berghei	Not reported	Not reported	[38,39,40]
		Plasmodium vinckei petteri	Not reported	Not reported
*In vitro models*
CQ-sensitive	3D7	P. falciparum	Not reported	Parasite lactate dehydrogenase (pLDH) assay	[41, 42]
			Not reported	Parasite growth inhibition assay	[43]
			Not reported	Translation inhibitory assay	[44]
	D6	P. falciparum	Sierra Leone	Incorporated G-³H hypoxanthine assay	[41, 42, 45, 46]
				Parasite lactate dehydrogenase (pLDH) assay	[47, 48]
				Non-radioactive Malaria SYBR Green I assay	[49, 50]
				Modified non-radioactive Malaria SYBR Green I assay	[42, 49, 51]
	D10	P. falciparum	Not reported	pLDH assay	[42, 52]
	F₃₂	P. falciparum	Tanzania	Not reported
	FCA20	P. falciparum	Ghana	Not reported
	K1	P. falciparum	Thailand	Modified [³H]-hypoxanthine incorporation assay and [³H]-hypoxanthine incorporation assay	[53,54,55,56]
	NF54	P. falciparum	Not reported	[³H]-hypoxanthine incorporation assay	[53,54,55,56]
CQ-resistant	Dd2	P. falciparum	Not reported	Non-radioactive Malaria SYBR Green I assay	[49, 50]
	FcM₂₉	P. falciparum	Cameroon	Not reported
	FcB1	P. falciparum	Colombia	[³H]-hypoxanthine incorporation assay	[41]
	K1	P. falciparum	Thailand	Modified [³H]-hypoxanthine incorporation assay and [³H]-hypoxanthine incorporation assay	[53,54,55,56]
	W2	P. falciparum	Indochina	Modified non-radioactive Malaria SYBR Green I assay	[42, 49, 51]
				Incorporated G-³H hypoxanthine assay	[45, 46]
				Non-radioactive Malaria SYBR Green I assay	[49, 50]
	NF54	P. falciparum		[³H]-hypoxanthine incorporation assay	[41]
CQ- and pyrimethamine-resistant	K1	P. falciparum	Thailand	Modified [³H]-hypoxanthine incorporation assay and [³H]-hypoxanthine incorporation assay	[53,54,55]
CQ- and pyrimethamine-resistant	NF54	P. falciparum	Thailand	[³H]-hypoxanthine incorporation assay	[54]
Multidrug-resistant	Dd2	P. falciparum	Not reported	[³H]-hypoxanthine incorporation assay	[53,54,55,56]
	K1	P. falciparum	Thailand	Parasite lactate dehydrogenase (pLDH) assay	[52, 57]
	NF54	P. falciparum	Not reported	[³H]-hypoxanthine incorporation assay	[53,54,55,56]
	W2	P. falciparum	Indochina	[³H]-hypoxanthine incorporation assay	[45, 46]
	W2mef	P. falciparum	Not reported	[³H]-hypoxanthine incorporation assay	[53,54,55,56]

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