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Table 1 Summary of testing methodologies and parasite strains described in this report

From: The potential of anti-malarial compounds derived from African medicinal plants: a review of pharmacological evaluations from 2013 to 2019

Murine (in vivo) models Strains Parasite name Origin Assay description References
CQ-sensitive NK 173 Plasmodium berghei Not reported Not reported  
ANKA P. berghei Not reported Not reported [38,39,40]
  Plasmodium vinckei petteri Not reported Not reported  
In vitro models
 CQ-sensitive 3D7 P. falciparum Not reported Parasite lactate dehydrogenase (pLDH) assay [41, 42]
Not reported Parasite growth inhibition assay [43]
Not reported Translation inhibitory assay [44]
D6 P. falciparum Sierra Leone Incorporated G-3H hypoxanthine assay [41, 42, 45, 46]
Parasite lactate dehydrogenase (pLDH) assay [47, 48]
Non-radioactive Malaria SYBR Green I assay [49, 50]
Modified non-radioactive Malaria SYBR Green I assay [42, 49, 51]
D10 P. falciparum Not reported pLDH assay [42, 52]
F32 P. falciparum Tanzania Not reported  
FCA20 P. falciparum Ghana Not reported  
K1 P. falciparum Thailand Modified [3H]-hypoxanthine incorporation assay and [3H]-hypoxanthine incorporation assay [53,54,55,56]
NF54 P. falciparum Not reported [3H]-hypoxanthine incorporation assay [53,54,55,56]
 CQ-resistant Dd2 P. falciparum Not reported Non-radioactive Malaria SYBR Green I assay [49, 50]
FcM29 P. falciparum Cameroon Not reported  
FcB1 P. falciparum Colombia [3H]-hypoxanthine incorporation assay [41]
K1 P. falciparum Thailand Modified [3H]-hypoxanthine incorporation assay and [3H]-hypoxanthine incorporation assay [53,54,55,56]
W2 P. falciparum Indochina Modified non-radioactive Malaria SYBR Green I assay [42, 49, 51]
Incorporated G-3H hypoxanthine assay [45, 46]
Non-radioactive Malaria SYBR Green I assay [49, 50]
NF54 P. falciparum   [3H]-hypoxanthine incorporation assay [41]
 CQ- and pyrimethamine-resistant K1 P. falciparum Thailand Modified [3H]-hypoxanthine incorporation assay and [3H]-hypoxanthine incorporation assay [53,54,55]
NF54 P. falciparum Thailand [3H]-hypoxanthine incorporation assay [54]
 Multidrug-resistant Dd2 P. falciparum Not reported [3H]-hypoxanthine incorporation assay [53,54,55,56]
K1 P. falciparum Thailand Parasite lactate dehydrogenase (pLDH) assay [52, 57]
NF54 P. falciparum Not reported [3H]-hypoxanthine incorporation assay [53,54,55,56]
W2 P. falciparum Indochina [3H]-hypoxanthine incorporation assay [45, 46]
W2mef P. falciparum Not reported [3H]-hypoxanthine incorporation assay [53,54,55,56]