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Table 8 Summary of other compound classes

From: The potential of anti-malarial compounds derived from African medicinal plants: a review of pharmacological evaluations from 2013 to 2019

Compound subclass

Isolated metabolites

Plasmodial strain (activities)

Plant species (Family), Taxon IDa

Part of the plant studied

Place of harvest (Locality, Country)

Author, references

Amide

174

3D7 (IC50 value = 39.04 µM)

Zanthoxylum heterophyllum (Rutaceae), NCBI:txid1908418

Leaves

Langevin, Reunion Island

Ledoux et al. [107]

Coumarins

175

3D7 (viability percentage = 101.15)

Diospyros conocarpa (Ebenaceae), NCBI:txid13492

Leaves, trunk, and roots

Ntouessong and Nkoemvone, Cameroon

Fouokeng et al. [108]

176, 177 and 178

NF54 (IC50 values vary from 2.17 to 60.09 µM)

Diospyros canaliculata (Ebenaceae), NCBI:txid13492

Stem bark

Kribi, Cameroon

Lenta et al. [90]

Ester

179

NF54 (IC50 value = 42.59 µM)

Erythrina caffra (Papilionaceae), NCBI:txid3842

Stem bark

Pietermaritzburg, South Africa

Chukwujekwu et al. [106]

Lactones

180

NF54 (IC50 value = 109.99 µM)

Vangueria infausta spp. infausta (Rubiaceae), NCBI:txid164485

Roots

Mutale Municipality, Limpopo Province, South Africa

Bapela [109]

181

D10 (IC50 value = 24.70 µM)

Lippia javanica (Verbenaceae), NCBI:txid925357

Leaves

Thathe Vondo village, Limpopo Province, South Africa

Ludere et al. [110]

Naphthalene derivatives

182 and 183

D6 (IC50 value = 10.52 µM for compound 182)

Kniphofia foliosa (Asphodelaceae), NCBI:txid214838

Rhizomes

Addis Ababa, Ethiopia

Induli et al. [85]

W2 (IC50 value = 6.32 µM for compound 182)

3D7 (IC50 value = 67.32 µM for compound 183)

182

D6 (IC50 value = 10.48 µM)

Kniphofia foliosa (Asphodelaceae), NCBI:txid214838

Roots

Gedo, Ethiopia

Abdissa n [86]

W2 (IC50 value = 6.28 µM)

Spirobisnaphthalene

184

NF54 (IC50 value = 73.28 µM)

Entandrophragma congoense (Meliaceae), NCBI:txid2590899

Bark

Nkomokui, Cameroon

Happi et al. [101]

Xanthones

185 to 187

F32/24h (IC50 values range from 1.16 to 70.33 µM)

Allanblackia floribunda (Guttiferae- Clusiaceae), NCBI:txid469914

Whole plant

Mount Kala, Cameroon

Azebaze et al. [78]

F32/72h (from 0.91 to 50.23 µM)

FCM29/24h (from 0.83 to 17.93 µM)

FCM29/24h (from 0.68 to 67.22 µM)

  1. aIdentification number of the source species, derived from the NCBI Taxonomy database