Skip to main content
Fig. 1 | Malaria Journal

Fig. 1

From: The thermostability of the RTS,S/AS01 malaria vaccine can be increased by co-lyophilizing RTS,S and AS01

Fig. 1

Evaluation of freshly reconstituted CL-vac. a Electronic microscopy analysis (TEM with negative staining) of reconstituted CL-vac (L) and reconstituted candidate RTS,S/AS01 two-vial formulation (R). White arrow, perforation of the liposome membrane. Thick black arrow, small liposome. Thin black arrow, RTS,S particles. Black bar represents 200 µm. b Interaction between antigen and adjuvant. RTS,S alone, AS01 alone, RTS,S/AS01 two-vial formulation (reconstituted vaccine) and CL-vac were centrifuged through a sucrose gradient. Five fractions were collected (fraction 1 at the top of the gradient, corresponding to low sucrose concentrations, and fraction 5 at the bottom). The concentration of RTS,S and DOPC and cholesterol (both AS01 components) were determined in the different fractions. The results showed no interaction between antigen in adjuvant in CL-vac, like in the RTS,S/AS01 two-vial formulation

Back to article page

Malaria Journal

ISSN: 1475-2875

Contact us