Fig. 8

Evolution of MPL congeners proportions upon storage. Liquid AS01 and CL-vac were stored at 4, 30, 37 or 45  °C for up to 12 months and the proportions of MPL congeners were determined at different time points. A short heat expedition was made for CL-vac consisting of 1 month at 45  °C after storage for 12 months at 30  °C and the proportions of MPL congeners were also measured at this final time point. The dashed lines indicate the respective accepted congener proportions set for the release of the adjuvant in liquid form (between 15 and 35%, 35 and 60%, and 20 and 40%, for tetra, penta and hexa, respectively)