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Table 4 Performance of uRDT and cRDT against qPCR. RECIPAL study, 2014–2017

From: Prevalence and clinical impact of malaria infections detected with a highly sensitive HRP2 rapid diagnostic test in Beninese pregnant women

 

PCR

Value (95%CI)a

(+)

(−)

Total

Sensitivityb

Specificityb

PPV

NPV

Positive LR

Negative LR

cRDT

 (+)

76

33

109

44.2%

95.7%

69.7%

88.5%

10.3

0.6

 (−)

96

737

833

(36.6–51.9)

(94.0–97.0)

(60.2–78.2)

(86.2–90.6)

(7.1–15)

(0.5–0.7)

uRDT

 (+)

104

49

153

60.5%

93.6%

68.0%

91.4%

9.5

0.4

 (−)

68

721

789

(52.7–67.8)

(91.7–95.3)

(60.0–75.3)

(89.2–93.2)

(7.1–12.8)

(0.3–0.5)

  1. PPV Predictive Positive Value, NPV Negative Predictive Value, LR Likelihood Ratio
  2. aFor all performance characteristics, exact binomial confidence intervals were computed
  3. bP-value < 0.05 using McNemar test for matched pairs