Table 5 Performance of uRDT and cRDT against qPCR, according to the trimester of pregnancy, gravidity, and presence of fever
URDT | CRDT | P-valuea | |
|---|---|---|---|
Sensitivity (95% CI) | |||
1st trimester | 57.0% (47.1–66.5) | 38.3% (29.1–48.2) | < 10−3 |
3rd trimester | 64.9% (47.5–79.8) | 54.1% (36.9–70.5) | 0.05 |
Delivery (peripheral blood) | 83.3% (58.6–96.4) | 61.1% (35.7–82.7) | 0.05 |
Delivery (placental blood) | 40.0% (12.2 –73.8) | 40.0% (12.2–73.8) | – |
Primi and Secundigravidae | 56.5% (41.1–71.1) | 43.5% (28.9–58.9) | 0.01 |
Multigravidae (3 +) | 63.6% (54.2–72.2) | 44.9% (35.7–54.3) | < 10−3 |
Asymptomatic | 60.8% (52.3–68.9) | 43.4% (35.1–51.9) | < 10−3 |
Symptomatic* | 66.7% (41.0 –86.7) | 50.0% (26.0–74.0) | 0.08 |
Specificity (95% CI) | |||
1st trimester | 91.5% (86.9–94.9) | 95.7% (92.1 –98.0) | 0.003 |
3rd trimester | 95.7% (92.0–98.0) | 97.1% (93.8–99.0) | 0.08 |
Delivery (peripheral blood) | 96.4% (92.2–98.7) | 97.6%(94.0–99.3) | 0.16 |
Delivery (placental blood) | 91.3% (86.3–94.9) | 92.4% (87.6–95.8) | 0.41 |
Primi and Secundigravidae | 93.9% (88.4–97.3) | 97.0% (92.4–99.2) | 0.05 |
Multigravidae (3 +) | 94.5% (92.1–96.3) | 96.3% (94.3–97.8) | 0.007 |
Asymptomatic | 94.6% (92.3–96.4) | 97.1% (95.3–98.4) | < 10−3 |
Symptomaticb | 92.2% (82.7–97.4) | 93.7% (84.8–98.3) | 0.32 |