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Table 5 Performance of uRDT and cRDT against qPCR, according to the trimester of pregnancy, gravidity, and presence of fever

From: Prevalence and clinical impact of malaria infections detected with a highly sensitive HRP2 rapid diagnostic test in Beninese pregnant women

  URDT CRDT P-valuea
Sensitivity (95% CI)
 1st trimester 57.0% (47.1–66.5) 38.3% (29.1–48.2) < 10−3
 3rd trimester 64.9% (47.5–79.8) 54.1% (36.9–70.5) 0.05
 Delivery (peripheral blood) 83.3% (58.6–96.4) 61.1% (35.7–82.7) 0.05
 Delivery (placental blood) 40.0% (12.2 –73.8) 40.0% (12.2–73.8) –
 Primi and Secundigravidae 56.5% (41.1–71.1) 43.5% (28.9–58.9) 0.01
 Multigravidae (3 +) 63.6% (54.2–72.2) 44.9% (35.7–54.3) < 10−3
 Asymptomatic 60.8% (52.3–68.9) 43.4% (35.1–51.9) < 10−3
 Symptomatic* 66.7% (41.0 –86.7) 50.0% (26.0–74.0) 0.08
Specificity (95% CI)
 1st trimester 91.5% (86.9–94.9) 95.7% (92.1 –98.0) 0.003
 3rd trimester 95.7% (92.0–98.0) 97.1% (93.8–99.0) 0.08
 Delivery (peripheral blood) 96.4% (92.2–98.7) 97.6%(94.0–99.3) 0.16
 Delivery (placental blood) 91.3% (86.3–94.9) 92.4% (87.6–95.8) 0.41
 Primi and Secundigravidae 93.9% (88.4–97.3) 97.0% (92.4–99.2) 0.05
 Multigravidae (3 +) 94.5% (92.1–96.3) 96.3% (94.3–97.8) 0.007
 Asymptomatic 94.6% (92.3–96.4) 97.1% (95.3–98.4) < 10−3
 Symptomaticb 92.2% (82.7–97.4) 93.7% (84.8–98.3) 0.32
  1. RECIPAL study, 2014–017
  2. aComparison of uRDT and cRDT performance using McNemar test for matched pairs. Exact binomial confidence intervals were computed
  3. bPresence of fever (axillary temperature ≥ 37.5 °C) or history of fever in the preceding 24 h, whether or not infected with malaria
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Malaria Journal

ISSN: 1475-2875

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