Prevalence and clinical impact of malaria infections detected with a highly sensitive HRP2 rapid diagnostic test in Beninese pregnant women

Table 6 HRP2 concentration and parasite density according to qPCR, uRDT and cRDT positivity. RECIPAL study, 2014–2017

	qPCR positive						qPCR negative
	N	HRP2 positive	Mean HRP2 (pg/mL)^b	95%CI	Mean qPCR density (parasites/µL) ^b	95%CI	N	HRP2 positive	Mean HRP2 (pg/mL)^b	95%CI
cRDT and uRDT positive	76	76	27,911	16,791–46,395	532	324–874	31	31^c	16,881	5597 –50,914
cRDT negative and uRDT positive	28	28	1049	757–1,455	20.7	10.8 –39.6	18	17^c	616	427–890
cRDT and uRDT negative	68	28	191	157–233	17	9 –30	718	58	160	135– 189

^aOut of 721 qPCR-negative specimens, 3 were not included in the Table 2 of them were cRDT-positive and uRDT-negative; and one (RDTs-negative) was not tested for HRP2
^bGeometric mean (95% confidence interval); HRP2 concentration and parasite density by qPCR calculated in positive HRP2 (qPCR) specimens
^cAmong the women at delivery who were qPCR negative in peripheral blood, but positive by uRDT and had detectable levels of HRP2, all of them (5/5) were negative by qPCR in placental blood

ISSN: 1475-2875