Table 4 Genetic analysis of Pfdhfr and Pfdhps SNPs in Plasmodium falciparum isolates collected from pregnant women at Msambweni County Referral Hospital in Kwale County, Kenya
SNP (N = 106) | Mutant type n (%, 95% CI) | Mixed type n (%, 95% CI) | Wild type n (%, 95% CI) |
|---|---|---|---|
a Prevalence of Pfdhfr and Pfdhps SNPs in isolated P. falciparum malaria parasites | |||
51 | 94 (88.68, 80.69 to 93.76) | 6 (5.66, 2.32 to 12.41) | 5 (4.72, 1.75 to 11.19) |
59 | 83 (78.30, 69.03 to 85.48) | 21 (19.81, 12.95 to 28.91) | 2 (1.89, 0.33 to 7.32) |
108 | 99 (93.40, 86.40 to 97.08) | 6 (5.66, 2.32 to 12.41) | 0 (0.00) |
437 | 100 (94.34, 87.59 to 97.68) | 4 (3.77, 1.21 to 9.94) | 2 (1.89, 0.33 to 7.32) |
540 | 97 (91.51, 84.07 to 95.80) | 1 (0.64, 0.05 to 5.90) | 5 (4.72, 1.75 to 11.19) |
Genotype | Mutants only | Mutants + Mixed | ||
|---|---|---|---|---|
N | % | N | % | |
b Different combinations of PfDHFR/PfDHPS haplotype mutations | ||||
Dup | 7 | 6.6 | 0 | 0 |
Tri | 7 | 6.6 | 4 | 3.8 |
Quad | 22 | 20.8 | 11 | 10.4 |
Quint | 70 | 66 | 91 | 85.8 |