Table 2 Evaluation of average % parasitaemia and % suppression of parasitaemia in Peters’ test
Groups | Compounds | Dose (mg/kg) | Average % parasitaemia ± SD (Day 4) | % Suppression of parasitaemia (Day 4) | Average % parasitaemia ± SD (Day 8) | P-value |
|---|---|---|---|---|---|---|
Oil | – | – | 5.33 ± 2.12 | – | 10.68 ± 1.11 | – |
DMSO | – | – | 7.41 ± 1.65 | – | 13.16 ± 1.47 | – |
CQ | – | 25 | 0 | 100 | 0 | – |
1 | 1a | 125 | 2.44 ± 1.56 | 61.69 | 3.20 ± 1.46 | |
1b | 62 | 3.37 ± 2.39 | 47.10 | 6.85 ± 0.45 | < 0.05 | |
1c | 31 | 5.86 ± 1.06 | 8.01 | 8.89 ± 2.25 | ||
2 | 2a | 125 | 0.06 ± 0.17 | 99.09 | 2.75 ± 0.84 | |
2b | 62 | 2.92 ± 2.79 | 54.16 | 4.85 ± 1.30 | < 0.05 | |
2c | 31 | 6.02 ± 1.79 | 5.49 | 9.30 ± 2.75 | ||
3 | 3a | 125 | 2.13 ± 1.75 | 66.50 | 2.55 ± 0.42 | |
3b | 62 | 3.68 ± 0.76 | 42.26 | 8.18 ± 0.97 | < 0.05 | |
3c | 31 | 1.35 ± 1.86 | 78.74 | 7.25 ± 1.07 | ||
4 | 4a | 125 | 1.95 ± 0.44 | 69.39 | 4.26 ± 2.17 | |
4b | 62 | 3.63 ± 2.51 | 43.01 | 7.54 ± 2.52 | < 0.05 | |
4c | 31 | 5.07 ± 2.54 | 20.41 | 9.96 ± 2.27 |