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Table 2 Evaluation of average  % parasitaemia and  % suppression of parasitaemia in Peters’ test

From: In silico and in vivo anti-malarial investigation on 1-(heteroaryl)-2-((5-nitroheteroaryl)methylene) hydrazine derivatives

Groups Compounds Dose (mg/kg) Average  % parasitaemia ± SD (Day 4) % Suppression of parasitaemia (Day 4) Average  % parasitaemia ± SD (Day 8) P-value
Oil 5.33 ± 2.12 10.68 ± 1.11
DMSO 7.41 ± 1.65 13.16 ± 1.47
CQ 25 0 100 0
1 1a 125 2.44 ± 1.56 61.69 3.20 ± 1.46  
1b 62 3.37 ± 2.39 47.10 6.85 ± 0.45 < 0.05
1c 31 5.86 ± 1.06 8.01 8.89 ± 2.25  
2 2a 125 0.06 ± 0.17 99.09 2.75 ± 0.84  
2b 62 2.92 ± 2.79 54.16 4.85 ± 1.30 < 0.05
2c 31 6.02 ± 1.79 5.49 9.30 ± 2.75  
3 3a 125 2.13 ± 1.75 66.50 2.55 ± 0.42  
3b 62 3.68 ± 0.76 42.26 8.18 ± 0.97 < 0.05
3c 31 1.35 ± 1.86 78.74 7.25 ± 1.07  
4 4a 125 1.95 ± 0.44 69.39 4.26 ± 2.17  
4b 62 3.63 ± 2.51 43.01 7.54 ± 2.52 < 0.05
4c 31 5.07 ± 2.54 20.41 9.96 ± 2.27  
  1. The in vivo activities were evaluated against Plasmodium berghei
  2. Italic values indicate the best compounds based on Peters’ test
  3. SD standard deviation