Table 3 Prevalence of polymorphisms in pfmdr1 and pfcrt before and after introduction of AL in Pakistan
2005–2007 (N = 240) [43] | 2007 (N = 28) [44] | 2011 (N = 171) [45] | 2018–2019 (N = 179) [current study] | |
|---|---|---|---|---|
Pfmdr1 N86Y | ||||
N86 | 43% | 67% | 80% | 77% |
86Y | 45% | 33%a | 4% | 16% |
N86Y (mixed) | 12% | Not stateda | 16% | 7% |
Pfmdr1 Y184F | ||||
Y184 | ND | ND | 75% | 83% |
184F | ND | ND | 0% | 11% |
Y184F (mixed) | ND | ND | 25% | 6% |
Pfmdr1 D1246Y | ||||
D1246 | ND | 100% | 100% | 100% |
1246Y | ND | 0% | 0% | 0% |
D1246Y (mixed) | ND | 0% | 0% | 0% |
Pfmdr1 CNV | ||||
Single copy | 99.6% (231/232)b | ND | 100% | ND |
Multiple copy | 0.4% (1/232)b | ND | 0% | ND |
Pfcrt K76T | ||||
K76 | 7% | 0% | 0% | 2% |
76T | 93% | 100% | 100% | 91% |
K76T (mixed) | 0% | 0% | 0% | 7% |