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Fig. 1 | Malaria Journal

Fig. 1

From: Prevalence of mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, and association with ex vivo susceptibility to common anti-malarial drugs against African Plasmodium falciparum isolates

Fig. 1

Dot plot of the IC50 values distribution of P. falciparum isolates from West Africa and Central Africa for chloroquine (CQ), quinine (QN), desethylamodiaquine (DQ), lumefantrine (LMF), mefloquine (MQ), piperaquine (PPQ), dihydroartemisinin (DHA), artesunate (AS) and pyronaridine (PND) according to I356T. Each dot represents the log10(IC50) for each isolate, red dots represent wild type I356 isolates (I), blue dots mutant 356T isolates (T) and yellow dots the log10(median IC50) value for each drug. The y-axis represents the log10(IC50) in nM. * Significant differences were found between wild type (I356) and mutant (356T) in West Africa (QN: p = 0.001, MQ: p = 0.01, PND: p = 0.005) and in Central Africa (QN: p = 0.02, MQ: p = 0.04, CQ: p = 0.01)

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Malaria Journal

ISSN: 1475-2875

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