Table 2 IC50 average parameters in nM for wild type (I356) and mutant (356T) P. falciparum isolates from West Africa and Central Africa for piperaquine (PPQ), quinine (QN), mefloquine (MQ), chloroquine (CQ), lumefantrine (LMF), desethylamodiaquine (DQ), pyronaridine (PND), dihydroartemisinin (DHA) and artesunate (AS)
Drugs | West Africa | Central Africa | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Wild type I356 | Mutant 356T | p value | Wild type I356 | Mutant 356T | p value | |||||
Median (no) | Min-Max | Median (no) | Min-Max | Median (no) | Min–Max | Median (no) | Min–Max | |||
PPQ | 22.2 (49) | 6.8–76.3 | 19.9 (66) | 1.2–544 | 0.32 | 24.5 (36) | 4.1–79 | 21.4 (70) | 0.67–96.3 | 0.4 |
QN | 69.1 (49) | 11.7–906.3 | 162.6 (68) | 6.2–590.5 | 0.001 | 98.2 (36) | 17.6–365.2 | 183.4 (73) | 28.9–538.4 | 0.02 |
MQ | 30.4 (49) | 2.9–89.8 | 22.4 (67) | 0.8–100.6 | 0.01 | 33.3 (38) | 0.7–97.9 | 21.5 (72) | 0.62–133.9 | 0.04 |
CQ | 37.4 (49) | 6.2–283.2 | 26.5 (68) | 5.5–359.5 | 0.1 | 42.8 (39) | 4.1–474.2 | 26.9 (73) | 5.79–325 | 0.01 |
LMF | 3.0 (49) | 0.5–61.54 | 4.0 (68) | 0.6–18.2 | 0.6 | 2.8 (40) | 0.6–15.5 | 3.6 (73) | 0.55–22.4 | 0.5 |
DQ | 19.2 (49) | 3.4–169.2 | 27.1 (68) | 2.5–185.1 | 0.07 | 22.8 (40) | 5.1–152.8 | 20.8 (73) | 4.7–152.9 | 0.4 |
PND | 8.8 (48) | 1.2–50.1 | 14.5 (66) | 0.7–119.3 | 0.005 | 11.1 (38) | 3.9–41 | 12.3 (67) | 0.2–47.9 | 0.8 |
DHA | 2.9 (49) | 0.4–8.3 | 3.1 (68) | 0.2–12.8 | 0.9 | 3.5 (40) | 0.7–7.7 | 2.1 (73) | 0.47–11.1 | 0.08 |
AS | 1.8 (49) | 0.4–15.48 | 1.8 (67) | 0.2–9.8 | 0.6 | 2.5 (39 | 0.6–5.7 | 1.7 (71) | 0.29–30.2 | 0.05 |