Fig. 3

Effect of CoPPIX on the development of malarial infection. Animals received daily i.p. injection of saline with 0.5% DMSO (Saline) or 5 mg/kg of CoPPIX (CoPPIX). Blood smears were used to analyse the parasitaemia. a HO-1 expression increased after CoPPIX treatment, after 9 days infection. b Survival curve during 15 days. c Parasitaemia during 12 days, representative of three experiments, where *p ≤ 0.05 when compared to infected animals in relation to uninfected controls, and (#) indicates p ≤ 0.05 infected animals treated with CoPPIX in relation to infected animals treated with saline. P values were calculated using an unpaired Ordinary one-way ANOVA test