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Table 3 Prevalence of pfcrt, pfmdr1, pfdhfr and pfdhps haplotypes in P. falciparum isolates from day 3 positive and negative patients after artemether-lumefantrine treatment

From: Efficacy of artemether-lumefantrine for treating uncomplicated Plasmodium falciparum cases and molecular surveillance of drug resistance genes in Western Myanmar

Gene Mutants Haplotype n (%) Pa
Day 3 positive, n = 4 Day 3 negative, n = 26 Total, n = 30
pfk13 Wild type K189 0 (0.0) 10 (38.5) 10 (33.3) 0.272
Single T189 0 (0.0) 3 (11.5) 3 (10.0) 1.000
NN K189 4 (100.0) 13 (50.0) 17 (56.7) 0.113
pfcrt Double T76S220 4 (100.0) 26 (100.0) 30 (100) 1.000
pfmdr1 Wild type Y184G968 3 (75.0) 19 (73.1) 22 (73.3) 1.000
Single F184G968 1 (25.0) 6 (23.1) 7 (23.3) 1.000
Y184A968 0 (0.0) 1 (3.8) 1 (3.3) 1.000
pfdhps Single S436G437K540A581 0 (0.0) 2 (7.7) 2 (6.7) 1.000
Double S436G437E540A581 0 (0.0) 3 (11.5) 3 (10.0) 1.000
A436G437K540A581 0 (0.0) 1 (3.8) 1 (3.3) 1.000
Triple S436G437E540G581 0 (0.0) 1 (3.8) 1 (3.3) 1.000
A436G437E540A581 4 (100.0) 19 (73.1) 23 (76.7) 0.548
pfdhfr Double N51R59N108I164 0 (0.0) 2 (7.7) 2 (6.7) 1.000
Triple N51R59N108L164 0 (0.0) 4 (15.4) 4 (13.3) 1.000
I51R59N108I164 1 (25.0) 5 (19.2) 6 (20.0) 1.000
Quadruple I51R59N108L164 3 (75.0) 15 (57.7) 18 (60.0) 0.632
pfdhpspfdhfr Quadruple S436G437K540A581–N51R59N108L164 0 (0.0) 2 (7.7) 2 (6.7) 1.000
S436G437E540A581–N51R59N108I164 0 (0.0) 1 (3.8) 1 (3.3) 1.000
Quintuple S436G437E540A581I51R59N108I164 0 (0.0) 2 (7.7) 2 (6.7) 1.000
> Quintuple S436G437E540G581I51R59N108I164 0 (0.0) 1 (3.8) 1 (3.3) 1.000
A436G437K540A581I51R59N108L164 0 (0.0) 1 (3.8) 1 (3.3) 1.000
A436G437E540A581–N51R59N108I164 0 (0.0) 1 (3.8) 1 (3.3) 1.000
A436G437E540A581–N51R59N108L164 0 (0.0) 2 (7.7) 2 (6.7) 1.000
A436G437E540A581I51R59N108I164 1 (25.0) 2 (7.7) 3 (10.0) 0.360
A436G437E540A581I51R59N108L164 3 (75.0) 14 (53.8) 17 (56.7) 0.613
  1. Mutant amino acids are highlighted in bold
  2. aComparison between the two groups by Fisher’s exact test. Sequences with mixed types were excluded for haplotype analysis