Fig. 4
From: Human plasma plasminogen internalization route in Plasmodium falciparum-infected erythrocytes
Model proposed for human plasminogen internalization in Plasmodium falciparum-infected erythrocytes. A possible route for the transport of plasminogen is through the exomembrane system in cytosolic erythrocytes (MCs, TVNs). Once in the parasitophorous vacuole, plasminogen is transported by a different pathway, with the passage through the PM, from that used for haemoglobin uptake (cytostome-derived endocytic vesicles—EV). Inside the parasite, plasminogen is located in its cytosol. TVN tubovesicular Network, MC Maurer’s Clefts, PVM parasitophorous vacuole membrane, PM parasite membrane, FV food vacuole, N nucleus