Skip to main content

Table 3 Assessing the predictive effect of each malaria antibody and FCGR3B polymorphisms on the risk of malaria

From: Evaluating the predictive performance of malaria antibodies and FCGR3B gene polymorphisms on Plasmodium falciparum infection outcome: a prospective cohort study

Model specification LR, p-value BCV AUROC BCV BS (%) RMSE R2
F + log.IgGAMA1 12.23, 0.0301 55 10 0.3511 2.0
F + log.IgG1AMA1 14.09, 0.0223 57 10 0.3501 2.0
F + log.IgG2AMA1 5.76, 0.8058 49 12 0.3400 1.0
F + log.IgG3AMA1 10.41, 0.7668 54 12 0.3525 2.0
F + log.IgG4AMA1 7.03, 0.7668 50 12 0.3439 3.0
F + log.IgGGLURPR0 7.41, 0.6501 51 12 0.3514 1.0
F + log.IgG1GLURPR0 6.93, 0.6987 51 12 0.3518 0.0
F + log.IgG2GLURPR0 6.38, 0.7528 50 12 0.3512 1.0
F + log.IgG3GLURPR0 5.99, 0.7872 49 12 0.3532 1.0
F + log.IgG4GLURPR0 6.13, 0.7716 50 12 0.3517 1.0
F + log.IgGGLURPR2 7.98, 0.5923 53 12 0.3518 1.0
F + log.IgG1GLURPR2 8.62, 0.6135 52 12 0.3512 1.0
F + log.IgG2GLURPR2 6.81, 0.7672 49 12 0.3514 1.0
F + log.IgG3GLURPR2 6.68, 0.7754 50 12 0.3812 1.0
F + log.IgG4GLURPR2 6.18, 0.7671 50 12 0.3909 2.0
F + log.IgGMSP1 6.60, 0.7302 51 12 0.3609 0.0
F + log.IgG1MSP1 6.03, 0.7812 50 12 0.3512 1.0
F + log.IgG2MSP1 6.53, 0.7369 50 12 0.3517 0.0
F + log.IgG3MSP1 5.78, 0.8059 49 12 0.3518 0.0
F + log.IgG4MSP1 5.81, 0.8032 49 12 0.3547 1.0
F + log.IgGMSP3 8.08, 0.5816 52 12 0.3558 0.0
F + log.IgG1MSP3 8.41, 0.6146 52 12 0.3678 1.0
F + log.IgG2MSP3 5.96, 0.7897 50 12 0.3579 2.0
F + log.IgG3MSP3 6.68, 0.7217 50 12 0.3510 1.0
F + log.IgG4MSP3 5.81, 0.8029 50 12 0.3512 2.0
F + Additive c.108C>G 7.81, 0.6743 51 12 0.3484 0.5
F + Additive c.114T>C 6.3, 0.8108 49 12 0.3501 0.5
F + Additive c.194A>G 7.42, 0.7103 50 12 0.3474 1.1
F + Additive c.233C>A 8.76, 0.5557 51 12 0.3470 1.3
F + Additive c.244A>G 8.51, 0.6066 51 12 0.3464 1.6
F + Additive c.316A>G 6.51, 0.7894 50 12 0.3483 0.6
F + Dominant c.108C>G 7.83, 0.6025 52 12 0.3455 2.1
F + Dominant c.114T>C 5.76, 0.8029 50 12 0.3458 2.0
F + Dominant c.194A>G 7.44, 0.6411 51 12 0.3467 1.5
F + Dominant c.233C>A 8.99, 0.0456 58 11 0.3166 2.4
F + Dominant c.244A>G 5.79, 0.8011 49 12 0.3491 0.1
F + Dominant c.316A>G 6.46, 0.7319 51 12 0.3476 1.0
F + Recessive c.108C>G 6.05, 0.7769 49 12 0.3454 2.2
F + Recessive c.114T>C 6.23, 0.7597 49 12 0.3487 0.3
F + Recessive c.194A>G 6.07, 0.7731 49 12 0.3480 0.7
F + Recessive c.233C>A 6.36, 0.7468 50 12 0.3500 0.4
F + Recessive c.244A>G 8.26, 0.5566 52 12 0.3470 1.3
F + Recessive c.316A>G 6.1, 0.7735 49 12 0.3479 0.8
  1. F: Penalized maximum likelihood model (PMLE.model), LR: Likelihood Ratio test statistic; BCV: Bootstrap cross-validation; RMSE: Root Mean Squared Error; R2: Proportion of explained variation in predicted risk; AUCROC: Area Under the Receiver Operating Characteristic curve, BS: Brier score