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Table 1 Performance of the uRDT against Q-Plex ELISA and microscopy detection

From: Ultra-sensitive RDT performance and antigen dynamics in a high-transmission Plasmodium falciparum setting in Mali

  HRP2 Q-Plex ELISA reference, % (95% CI) pLDH Q-Plex ELISA reference, % (95% CI) Microscopy reference, % (95% CI)
Sensitivity 58% (53–63) 68% (63–74) 78% (71–84)
Specificity 100% (100–100) 84% (80–88) 74% (70–78)
PPV 100% (100–100) 78% (73–83) 51% (45–57)
NPV 53% (48–58) 77% (72–81) 90% (87–93)
  1. Results are given with associated 95% CIs. Whole blood samples were defined as HRP2- and pLDH-positive with concentrations > 2.30 pg/mL and > 47.8 pg/mL, respectively. Microscopy-positive samples were those with any P. falciparum parasites detected per 1000 WBCs
  2. ELISA enzyme-linked immunosorbent assay, LDH lactate dehydrogenase, PPV positive predicted value, NPV negative predicted value