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Table 1 Performance of the uRDT against Q-Plex ELISA and microscopy detection

From: Ultra-sensitive RDT performance and antigen dynamics in a high-transmission Plasmodium falciparum setting in Mali

 

HRP2 Q-Plex ELISA reference, % (95% CI)

pLDH Q-Plex ELISA reference, % (95% CI)

Microscopy reference, % (95% CI)

Sensitivity

58% (53–63)

68% (63–74)

78% (71–84)

Specificity

100% (100–100)

84% (80–88)

74% (70–78)

PPV

100% (100–100)

78% (73–83)

51% (45–57)

NPV

53% (48–58)

77% (72–81)

90% (87–93)

  1. Results are given with associated 95% CIs. Whole blood samples were defined as HRP2- and pLDH-positive with concentrations > 2.30 pg/mL and > 47.8 pg/mL, respectively. Microscopy-positive samples were those with any P. falciparum parasites detected per 1000 WBCs
  2. ELISA enzyme-linked immunosorbent assay, LDH lactate dehydrogenase, PPV positive predicted value, NPV negative predicted value