Skip to main content

Table 1 General characteristics of study subjects and exposure to potential drug–drug interactions

From: Potential drug–drug interactions associated with adverse clinical outcomes and abnormal laboratory findings in patients with malaria

General characteristics Patients: n (%) Exposure to pDDIs [Patients: n (%)]
Gender
 Male 206 (51.8) 77 (37.4)
 Female 192 (48.2) 71 (37)
Age (years)
 ≤ 20 96 (24.1) 40 (41.7)
 21–40 176 (44.2) 53 (30.1)
 > 40 126 (31.7) 55 (43.7)
 Median (interquartile range) 30 (22-50)  
Drugs prescribed
 < 5 78 (19.6) 5 (6.4)
 ≥ 5 320 (80.4) 143 (44.7)
 Median (interquartile range) 7 (5–9)  
Hospital stay (days)
 ≤ 3 141 (35.4) 32 (22.7)
 4–5 144 (36.2) 56 (38.9)
 > 5 113 (28.4) 60 (53.1)
 Median (interquartile range) 4 (3–6)  
Number of comorbidities
 No comorbidities 179 (45)
 1–2 187 (46.9)
 ≥ 3 32 (8)
Comorbidities
 Hypertension 52 (13.1) 20 (38.5)
 Diabetes mellitus 45 (11.3) 27 (60)
 Urinary tract infection 34 (8.5) 13 (38.2)
 Hepatitis 23 (5.8) 11 (47.8)
 Ischemic heart disease 15 (3.8) 9 (60)
 Anaemia 13 (3.3) 3 (23.1)
 Dengue fever 12 (3) 5 (41.7)
 Meningitis 11 (2.8) 5 (41.7)
 Respiratory tract infection 9 (2.3) 2 (22.2)
 Thrombocytopenia 9 (2.3) 2 (22.2)
 Typhoid 9 (2.3)
 Bicytopenia 7 (1.8)
 Acute gastroenteritis 6 (1.5)
 Asthma 6 (1.5)
 Tuberculosis 6 (1.5)
 Acute kidney injury 5 (1.3)
 Pancytopenia 5 (1.3)
 Decompensated chronic liver disease 4 (1)
 Pneumonia 4 (1)
 Congestive cardiac failure 3 (0.8) each
 Miscellaneous 72 (18)a
  1. pDDIs potential drug–drug interactions
  2. aIn miscellaneous the following diagnosis were reported: chronic obstructive pulmonary disease, depression, encephalitis, epilepsy, goiter, hepatic encephalopathy, herpes labialis, post-natal endometriosis, thalassemia, deep vein thrombosis as n = 3 (0.8%) each. While, cholelithiasis, fits, nephropathy, pleural effusion as n = 2 (0.5%) each. However, achondroplasia, aortic stenosis, arthritis, atrial fibrillation, cellulitis, dementia, disseminated intravascular coagulation, down syndrome, endocarditis, eosinophilia, hyponatremia, hypothyroidism, immune thrombocytopenic purpura, leukemia, liver abscess, left ventricular failure, lymphoma, malignancy, menorrhagia, multiple myeloma, osteoporosis, post splenectomy, psychiatric disorder, rheumatic heart disease, renal tubular acidosis, systemic lupus erythematosus, spondylosis, sexually transmitted disease, stroke, thyrotoxicosis, tonsillitis, ulcerative colitis, urosepsis, Wilson disease as n = 1 (0.3%) each