Table 11 Repeated dose 14-day toxicokinetics study in male and female Sprague–Dawley Rats
TK Parameters | FNDR-20123 (100Â mg/kg bw) | |||
|---|---|---|---|---|
Male | Female | |||
Day 1 | Day 14 | Day 1 | Day 14 | |
Cmax (ng/mL) | 420.04 ± 174.42 | 702.66 ± 362.42 | 228.72 ± 69.32 | 206.96 ± 36.13 |
Tmax (h) | 0.33 ± 0.14 | 0.19 ± 0.10 | 0.28 ± 0.21 | 0.14 ± 0.10 |
AUClast (h*ng/mL) | 711.78 ± 233.81 | 956.67 ± 180.88 | 344.65 ± 71.63 | 480.15 ± 49.73 |
AUCinf (h*ng/mL) | 1278.86 ± 282.19 | 1075.02 ± 215.59 | 448.27 ± 112.83 | 573.42 ± 23.07 |
T1/2 (h) | 5.72 ± 4.10 | 2.30 ± 0.55 | 3.21 ± 0.41 | 2.40 ± 0.26 |