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Table 11 Repeated dose 14-day toxicokinetics study in male and female Sprague–Dawley Rats

From: Discovery of FNDR-20123, a histone deacetylase inhibitor for the treatment of Plasmodium falciparum malaria

TK Parameters FNDR-20123 (100 mg/kg bw)
Male Female
Day 1 Day 14 Day 1 Day 14
Cmax (ng/mL) 420.04 ± 174.42 702.66 ± 362.42 228.72 ± 69.32 206.96 ± 36.13
Tmax (h) 0.33 ± 0.14 0.19 ± 0.10 0.28 ± 0.21 0.14 ± 0.10
AUClast (h*ng/mL) 711.78 ± 233.81 956.67 ± 180.88 344.65 ± 71.63 480.15 ± 49.73
AUCinf (h*ng/mL) 1278.86 ± 282.19 1075.02 ± 215.59 448.27 ± 112.83 573.42 ± 23.07
T1/2 (h) 5.72 ± 4.10 2.30 ± 0.55 3.21 ± 0.41 2.40 ± 0.26