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Table 4 Summary of physiological properties and anti-malarial activity of FNDR-20123

From: Discovery of FNDR-20123, a histone deacetylase inhibitor for the treatment of Plasmodium falciparum malaria

Compound

Physicochemical properties

Hu HDAC IC50 (nM)

PfHDAC1

Anti-malarial activity

 

Mol. Wt.

ClogP

PSA

HeLa nuclear extract

IC50 (nM)

Asexual Blood Stage IC50 (nM)

Gametocytes IC50 (nM) Male/Female

FNDR-20123

377.45

1.917

80.53

3

31

41

190/> 5000

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Malaria Journal

ISSN: 1475-2875

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