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Table 4 Summary of physiological properties and anti-malarial activity of FNDR-20123

From: Discovery of FNDR-20123, a histone deacetylase inhibitor for the treatment of Plasmodium falciparum malaria

Compound Physicochemical properties Hu HDAC IC50 (nM) PfHDAC1 Anti-malarial activity
  Mol. Wt. ClogP PSA HeLa nuclear extract IC50 (nM) Asexual Blood Stage IC50 (nM) Gametocytes IC50 (nM) Male/Female
FNDR-20123 377.45 1.917 80.53 3 31 41 190/> 5000