(a) | Mutated locus | Mutations (amino acid changes) | FNDR-20123 | ||
---|---|---|---|---|---|
IC50 (nM) | Fold shift IC50 rel. Dd2 | ||||
Dd2 | Wild type | N/A | 17.50 | 1.0 | |
Dd2 DDD107498 | PfeEF2 | Y186N | 20.86 | 1.2 | |
Dd2 390048 | Pfpi4k | S743T | 18.27 | 1.0 | |
Dd2 DSM265 | Pfdhodh | G181C | 17.83 | 1.0 | |
Dd2 GNF156 | Pfcarl | Ile1139Lys | 18.45 | 1.1 | |
Dd2 ELQ300 | PfcytB | Ile22Leu | 13.49 | 0.8 | |
(b) | FNDR-20123 | ||||
IC50 (nM) | Fold shift IC50 rel. NF54 | ||||
 NF54 | 25.27 | 1.0 | |||
 K1 | 19.05 | 0.75 | |||
 7G8 | 14.36 | 0.57 | |||
 TM90C2B | 13.26 | 0.52 | |||
 Cam3.I (MRA1240) | 22.06 | 0.87 | |||
 Dd2 | 17.50 | 0.69 |