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Table 5 (a) Cross-resistance profile of FNDR-20123 (b) Hypersensitivity profile of FNDR-20123

From: Discovery of FNDR-20123, a histone deacetylase inhibitor for the treatment of Plasmodium falciparum malaria

(a) Mutated locus Mutations (amino acid changes) FNDR-20123
IC50 (nM) Fold shift IC50 rel. Dd2
Dd2 Wild type N/A 17.50 1.0
Dd2 DDD107498 PfeEF2 Y186N 20.86 1.2
Dd2 390048 Pfpi4k S743T 18.27 1.0
Dd2 DSM265 Pfdhodh G181C 17.83 1.0
Dd2 GNF156 Pfcarl Ile1139Lys 18.45 1.1
Dd2 ELQ300 PfcytB Ile22Leu 13.49 0.8
(b) FNDR-20123
IC50 (nM) Fold shift IC50 rel. NF54
 NF54 25.27 1.0
 K1 19.05 0.75
 7G8 14.36 0.57
 TM90C2B 13.26 0.52
 Cam3.I (MRA1240) 22.06 0.87
 Dd2 17.50 0.69