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Table 7 Pharmacokinetic parameters of FNDR-20123

From: Discovery of FNDR-20123, a histone deacetylase inhibitor for the treatment of Plasmodium falciparum malaria

  Infected Normal Normal Normal
Animal, strain SCID mice Balb/C mice Balb/C mice Balb/C mice
Route of administration Oral Oral Subcutaneous Intramuscular
Dose (mg/Kg) 50 50 50 50
Tmax (h) 1.00 1.00 0.08 0.08
Cmax (ng/mL) 460 184 14039 15654
AUClast (h*ng/mL) 1340 327 10,981 7224
t1/2 (h) Not calculated 2.02 9.21 8.72
  1. Values are expressed as Mean ± SD
  2. N = 3 mice