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Table 9 Summary of Relative Organ Weights (g)–Males

From: Discovery of FNDR-20123, a histone deacetylase inhibitor for the treatment of Plasmodium falciparum malaria

Groups, sex and dose (mg/kg) Fasting body weight (g) Mean ± SD Brain Heart Liver Kidney Thymus Spleen Lungs Testis Epididymis
G1 M 0 191.68 0.92 0.35 4.02 0.91 0.13 0.48 0.96 1.45 0.30
19.15 0.10 0.03 0.34 0.13 0.06 0.10 0.67 0.13 0.05
G2 M 50 189.75 0.91 0.36 4.13 0.88 0.09 0.38 0.69 1.44 0.26
8.99 0.06 0.00 0.56 0.10 0.04 0.14 0.07 0.10 0.05
G3 M 100 163.82 1.25 0.46 5.62 1.12 0.10 0.80 0.99 1.94 0.28
38.21 0.15 0.14 2.73 0.44 0.04 0.87 0.37 0.59 0.11
G4 M 150 174.95 0.98 0.35 3.72 0.91 0.10 0.21 0.76 1.54 0.34
11.67 0.11 0.04 0.39 0.08 0.02 0.07 0.15 0.16 0.07
  1. G5-toxicokinetic group
  2. Values are in Mean ± SD; G1 vs G2, G3 & G4 (*p < 0.05)