Table 2 Frequencies of mutation appearance in three time groups (%)
From: Kelch 13-propeller polymorphisms in Plasmodium falciparum from Jazan region, southwest Saudi Arabia
No | Mutation | 2011 samples (N = 20) | 2016 samples (N = 40) | 2020 samples (N = 80) | Total (N = 140) |
|---|---|---|---|---|---|
1 | *P441A | 1 (5%) | 1 (0.7%) | ||
2 | *P443T | – | – | 2 (2.5%) | 2 (1.4%) |
3 | ***F446L | 1 (5%) | 1 (0.7%) | ||
4 | C447R | 4 (5%) | 4 (2.9%) | ||
5 | F451Y | 4 (10%) | 4 (2.9%) | ||
6 | **V454A | 1 (2.5%) | 1 (1.25%) | 2 (1.4%) | |
7 | L457S | 4 (10%) | 4 (2.9%) | ||
8 | *N458T | 6 (15%) | 3 (3.75%) | 9 (6.4%) | |
9 | *M476I | 1 (2.5%) | 1 (1.25%) | 2 (1.4%) | |
10 | N531S | 1 (1.25%) | 1 (0.7%) | ||
11 | N537S | 1 (1.25%) | 1 (0.7%) | ||
12 | *G538N | 1 (1.25%) | 1 (0.7%) | ||
13 | S550C | 1 (1.25%) | 1 (0.7%) | ||
14 | P574R | 1 (1.25%) | 1 (0.7%) | ||
15 | A578G | 1 (1.25%) | 1 (0.7%) | ||
16 | **D584V | – | – | 4 (5%) | 4 (2.9%) |
17 | *S623N | 1 (5%) | 2 (5%) | – | 3 (2.1%) |
18 | **A626P | – | 2 (5%) | – | 2 (1.4%) |
19 | A627P | – | 2 (5%) | 1 (1.25%) | 3 (2.1%) |
20 | ***Y630F | – | 2 (5%) | – | 2 (1.4%) |
21 | D648N | – | 4 (10%) | – | 4 (2.9%) |
22 | Q652P | – | 2 (5%) | 1 (1.25%) | 3 (2.1%) |
23 | N657I | 3 (15%) | 2 (5%) | 1 (1.25%) | 6 (4.3%) |
24 | K658I | 4 (20%) | 1 (2.5%) | – | 5 (3.6%) |
22 | L663V | 1 (5%) | 3 (7.5%) | – | 4 (2.9%) |
26 | **V666A | 1 (5%) | 1 (2.5%) | 1(1.25%) | 3 (2.1%) |
27 | K670E | 3 (15%) | – | – | 3 (2.1%) |
28 | M671I | 2 (10%) | 2 (5%) | 2 (2.5%) | 6 (4.3%) |
29 | *F673S | 2 (10%) | – | – | 2 (1.4%) |
30 | ***A675S | 1 (5%) | – | 1 (1.25%) | 2 (1.4%) |
31 | ***A676V | 1 (5%) | – | – | 1 (0.7%) |
32 | T677S | 3 (15%) | – | – | 3 (2.1%) |
33 | L678S | 3 (15%) | – | 2 (1.25%) | 5 (3.6%) |
34 | *S679A | 2 (10%) | – | 3 (3.75%) | 5 (3.6%) |
35 | **D680N | 1 (5%) | 1 (2.5%) | 1 (1.25%) | 3 (2.1%) |
36 | I684T | 2 (10%) | 1 (2.5%) | 2 (2.5%) | 5 (3.6%) |
37 | T685S | 2 (10%) | 1 (2.5%) | 2 (2.5%) | 5 (3.6%) |
38 | G687R | – | – | 2 (2.5%) | 2 (1.4%) |
39 | E688A | 3 (15%) | 1 (2.5%) | 2 (2.5%) | 6 (4.3%) |
40 | N689S | – | – | 6 (7.5%) | 6 (4.3%) |
41 | N689G | – | – | 5 (6.25%) | 5 (3.6%) |
42 | V692I | 2 (10%) | 2 (5%) | 4 (5%) | 8 (5.7%) |
43 | L693R | – | 1 (2.5%) | 4 (5%) | 5 (3.6%) |
44 | L693G | 1 (5%) | – | 4 (5%) | 5 (3.6%) |
45 | N694I | – | – | 2 (2.5%) | 2 (1.4%) |
46 | F699C | 1 (5%) | 1 (2.5%) | 4 (5%) | 6 (3.6%) |
47 | F699I | – | 1 (2.5%) | 4 (5%) | 5 (3.6%) |
48 | P701L | – | – | 6 (7.5%) | 6 (4.3%) |
49 | D702H | 2 (10%) | 3 (7.5%) | 10 (12.5%) | 15 (10.7%) |
50 | T703A | 1 (5%) | – | 3 (3.75%) | 4 (2.9%) |
51 | L708H | – | 2 (5%) | 2(2.5%) | 4 (2.9%) |