Molecular surveillance of the Plasmodium vivax multidrug resistance 1 gene in Peru between 2006 and 2015

Malaria Journal

Table 1 Prevalence of nonsynonymous mutations by regions 2006–2015

SNPs	Regions						p-value^a	Total (n = 550)
	Northern Amazon Basin (n = 445)		Southern Amazon Basin (n = 48)		North Coast (n = 57)		p-value^a	Total (n = 550)
	n	%	n	%	n	%		n	%
L186W (TTG–> TGG)	14	3.1	0	0.0	0	0.0	0.269	14	2.5
V221L (GTG–> CTG)^b	58	13.0	0	0.0	10	17.5	0.001	68	12.4
D500N (GAT–> AAT)	29	6.5	0	0.0	1	1.8	0.062	30	5.5
M908L (ATG–> CTG)	441	99.1	47	97.9	57	100.0	0.437	545	99.1
T958M (ACG–> ATG)^b	413	92.8	48	100.0	56	98.2	0.039	517	94.0
Y976F (TAC–> TTC)^b	41	9.2	0	0.0	0	0.0	0.001	41	7.5
F1070L (TTC–> CTC)^b	12	2.7	0	0.0	10	17.5	0.001	22	4.0
F1076L (TTT–> CTT)^b	56	12.6	2	4.2	0	0.0	0.001	58	10.5

ISSN: 1475-2875