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Table 3 Changes in the frequency of Pfdhfr and Pfdhps genotypes between 1998 and 2020

From: Drug resistance markers within an evolving efficacy of anti-malarial drugs in Cameroon: a systematic review and meta-analysis (1998–2020)

Gene Mutation Allele 1998–2008 (%, n/N) 2009–2020 (%, n/N) P-value
Pfdhfr N51I N51 27.8 (765/2751) 33.1 (624/1887) P < 0.0001*
51I 72.2 (1986/2751) 66.9 (1263/1887)
C59R C59 23.5 (647/2751) 32.2 (621/1929) P < 0.0001*
59R 76.5 (2104//2751) 67.8 (1308/1929)
S108N S108 19.2 (569/2959) 32.4 (622/1921) P < 0.0001*
108 N 80.8 (2390/2959) 67.6 (1299/1921)
Pfdhps A437G A437 69.6 (477/685) 53.1 (1004/1890) P < 0.0001*
437G 30.4 (208/685) 46.9 (886/1890)
K540E K540 100.0 (433/433) 99.6 (1849/1856) P = 0.201
540E 0.0 (0/433) 0.4 (7/1856)
  1. *P < 0.05: Statistically significant, n: Number of amino acid substitutions, N: Total number of samples genotyped