Table 3 Changes in the frequency of Pfdhfr and Pfdhps genotypes between 1998 and 2020
Gene | Mutation | Allele | 1998–2008 (%, n/N) | 2009–2020 (%, n/N) | P-value |
|---|---|---|---|---|---|
Pfdhfr | N51I | N51 | 27.8 (765/2751) | 33.1 (624/1887) | P < 0.0001* |
51I | 72.2 (1986/2751) | 66.9 (1263/1887) | |||
C59R | C59 | 23.5 (647/2751) | 32.2 (621/1929) | P < 0.0001* | |
59R | 76.5 (2104//2751) | 67.8 (1308/1929) | |||
S108N | S108 | 19.2 (569/2959) | 32.4 (622/1921) | P < 0.0001* | |
108 N | 80.8 (2390/2959) | 67.6 (1299/1921) | |||
Pfdhps | A437G | A437 | 69.6 (477/685) | 53.1 (1004/1890) | P < 0.0001* |
437G | 30.4 (208/685) | 46.9 (886/1890) | |||
K540E | K540 | 100.0 (433/433) | 99.6 (1849/1856) | P = 0.201 | |
540E | 0.0 (0/433) | 0.4 (7/1856) |