|
Gene
|
Mutation
|
Allele
|
1998–2008 (%, n/N)
|
2009–2020 (%, n/N)
|
P-value
|
|---|
|
Pfdhfr
|
N51I
|
N51
|
27.8 (765/2751)
|
33.1 (624/1887)
|
P < 0.0001*
|
|
51I
|
72.2 (1986/2751)
|
66.9 (1263/1887)
|
|
C59R
|
C59
|
23.5 (647/2751)
|
32.2 (621/1929)
|
P < 0.0001*
|
|
59R
|
76.5 (2104//2751)
|
67.8 (1308/1929)
|
|
S108N
|
S108
|
19.2 (569/2959)
|
32.4 (622/1921)
|
P < 0.0001*
|
|
108 N
|
80.8 (2390/2959)
|
67.6 (1299/1921)
|
|
Pfdhps
|
A437G
|
A437
|
69.6 (477/685)
|
53.1 (1004/1890)
|
P < 0.0001*
|
|
437G
|
30.4 (208/685)
|
46.9 (886/1890)
|
|
K540E
|
K540
|
100.0 (433/433)
|
99.6 (1849/1856)
|
P = 0.201
|
|
540E
|
0.0 (0/433)
|
0.4 (7/1856)
|
- *P < 0.05: Statistically significant, n: Number of amino acid substitutions, N: Total number of samples genotyped
