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Table 5 Inhibitory concentrations of the affinity maturated antibodies against the P. falciparum strains 3D7, HB3, K1 and W2mef

From: Isolation and light chain shuffling of a Plasmodium falciparum AMA1-specific human monoclonal antibody with growth inhibitory activity

P. falciparum strain

EC50 (95%CI) (mg/mL)

Antibody

OcheA-9

OcheA-16

OcheA-17

OcheA-17B

3D7

1.19

> 2

0.55

0.29

(0.79–1.79)

 

(0.43–0.70)

(0.24–0.34)

HB3

1.07

1.18

0.45

0.23

(0.61–1.86)

(0.65–2.13)

(0.25–0.81)

(0.17–0.32)

K1

0.77

1.50

0.37

0.31

(0.49–1.21)

(0.79–2.87)

(0.24–0.55)

(0.26–0.38)

W2mef

0.55

> 2

0.30

> 2

(0.31–0.96)

 

(0.26–0.34)

 
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Malaria Journal

ISSN: 1475-2875

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