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Table 4 Sensitivity, specificity and predictive values of microscopy, routine Pf RDT and HSPf RDT compared to PCR as gold standard by age group

From: Performance evaluation of the highly sensitive histidine‐rich protein 2 rapid test for Plasmodium falciparum malaria in North-West Tanzania

Age Sensitivity % (95CI) Specificity % (95CI) PPV % (95CI) NPV % (95CI)
Microscopy
 5–10 52.5 (38.3–71.4) 93.7 (79.2–99.2) 91.3 (72.0–98.9) 61.2 (46.2–74.8)
 11–15 58.3 (46.8–81.4) 100 (80.5–100) 100 (83.9–100) 51.6 (33.1–69.8)
 > 15 28.2 (20.3–39.8) 91.4 (85.0–94.5) 65.1 (49.1–79.0) 69.1 (62.7–75.0)
 P-value* 0.070 0.001 0.98 0.886
Pf
 5–10 75 (58.8–87.3) 93.8 (79.2–99.2) 93.8 (79.2–99.2) 75 (58.8–87.3)
 11–15 77.8 (65.5–93.2) 75.0 (52.4–93.6) 87.5 (71.0–96.5) 60 (36.0–80.9)
 > 15 41.4 (32.3–52.7) 97.1 (93.5–99.1) 89.1 (76.4–96.4) 75.2 (69.1–80.7)
 P-value* 0.051 0.835 0.980 0.980
HSPf
 5–10 80.0 (64.4–90.9) 93.8 (79.2–99.2) 94.1 (80.3–99.3) 78.9 (62.7–90.4)
 11–15 86.1 (76.3–98.1) 62.5 (41.0–86.7) 83.8 (68.0–93.8) 67 (38.4–88.2)
 > 15 54.5 (45.2–65.8) 96.0 (91.9–98.4) 88.5 (77.8–95.3) 78.7 (72.6–84.1)
 P-value* 0.196 0.640 0.945 0.999
  1. Age shown in years, PPV positive predictive value, NPV negative predictive value, 95CI 95% confidence interval
  2. *Obtained from Pearson Chi-squared test
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