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Table 2 Comparison of qRT-PCR SBP-1 prevalence between SP–AQ and DP treatment arms over time

From: Persistence of mRNA indicative of Plasmodium falciparum ring-stage parasites 42 days after artemisinin and non-artemisinin combination therapy in naturally infected Malians

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SBP-1 qRT-PCR

Microscopy

Prevalence, n (%)

DP: SP–AQ

PR [95% CI]

p-value1

Prevalence, n (%)

DP: SP–AQ

PR [95% CI]

p-value1

All

SP–AQ

DP

All

SP–AQ

DP DP

Day 0

64 (89)

31 (89)

33 (89)

1.01 [0.86, 1.19]

0.93

43 (59)

24 (67)

19 (51)

0.77 [0.52, 1.14]

0.18

Day 1

54 (75)

29 (81)

25 (69)

0.86 [0.66, 1.13]

0.28

19 (26)

16 (44)

3 (8)

0.18 [0.05, 0.57]

0.0004

Day 2

45 (63)

25 (71)

20 (54)

0.76 [0.53, 1.09]

0.13

9 (12)

6 (17)

3 (8)

0.49 [0.13, 1.80]

0.27

Day 7

19 (26)

9 (25)

10 (27)

1.08 [0.50, 2.35]

0.84

1 (1)

0 (0)

1 (3)

–

–

Day 14

14 (19)

7 (19)

7 (19)

0.98 [0.38, 2.50]

0.96

1 (1)

1 (3)

0 (0)

–

–

Day 28

8 (11)

6 (17)

2 (5)

0.32 [0.07, 1.50]

0.15

1 (1)

1 (3)

0 (0)

–

–

Day 42

24 (33)

18 (50)

6 (17)

0.33 [0.15, 0.74]

0.0027

7 (11)

4 (11)

3 (8)

0.75 [0.18, 3.11]

0.69

  1. PR prevalence ratio, SP–AQ sulfadoxine–pyrimethamine and amodiaquine, DP dihydroartemisinin–piperaquine
  2. 1 p-values computed using Chi-squared test or Fisher’s exact test if any cell value in 2 × 2 table was less than five
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Malaria Journal

ISSN: 1475-2875

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