Skip to main content

Table 3 Associations between RBC variants and prevalence of microscopic parasitaemia at the time of each routine visit

From: Associations between red blood cell variants and malaria among children and adults from three areas of Uganda: a prospective cohort study

Age groupRed cell variantsVariantParasite prevalenceUnadjustedAdjusted*
PR (95% CI)p-valuePR (95% CI)p-value
ChildrenHaemoglobin variantAA2488/15,830 (15.7%)ReferenceReference
AS597/3636 (16.4%)1.07 (0.89–1.30)0.460.95 (0.80–1.13)0.57
SS3/66 (4.6%)0.31 (0.14–0.68)0.0040.31 (0.18–0.54)<0.001
Alpha thalassaemia variantNormal1621/11,664 (13.9%)ReferenceReference
alpha+ (α−/αα)1272/6397 (19.9%)1.45 (1.24–1.70)<0.0011.23 (1.06–1.43)0.008
alpha0 (α−/−α)127/937 (13.6%)0.96 (0.66–1.40)0.830.98 (0.66–1.44)0.91
G6PD genotypeNormal (male)1593/9147 (17.4%)ReferenceReference
Hemizygotes194/1030 (18.8%)1.09 (0.81–1.48)0.570.86 (0.65–1.14)0.30
Normal (female)887/7039 (12.6%)ReferenceReference
Heterozygotes372/2062 (18.0%)1.35 (1.04–1.75)0.021.13 (0.87–1.45)0.36
Homozygotes46/243 (18.9%)1.38 (0.75–2.54)0.300.92 (0.53–1.59)0.76
AdultsHaemoglobin variantAA187/3952 (4.7%)ReferenceReference
AS37/1050 (3.5%)0.72 (0.45–1.15)0.170.74 (0.45–1.22)0.24
Alpha thalassaemia variantNormal128/3307 (3.9%)ReferenceReference
alpha+ (α−/αα)81/1332 (6.1%)1.59 (1.08–2.34)0.021.52 (1.04–2.23)0.03
α−/−α15/290 (5.2%)1.35 (0.76–2.42)0.301.16 (0.63–2.14)0.64
G6PD genotypeNormal (male)8/229 (3.5%)referencereference
Hemizygotes7/79 (8.9%)2.48 (0.72–8.52)0.155.10 (0.58–44.9)0.14
Normal (female)173/3792 (4.6%)ReferenceReference
Heterozygotes37/880 (4.2%)0.87 (0.58–1.31)0.510.77 (0.52–1.15)0.20
Homozygotes3/50 (6.0%)1.38 (0.42–4.50)0.591.34 (0.44–4.05)0.61
  1. * Adjusted for age, average household EIR, and study site