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Fig. 3 | Malaria Journal

Fig. 3

From: The extended recovery ring-stage survival assay provides a superior association with patient clearance half-life and increases throughput

Fig. 3

120 h eRRSA increases correlation with PC1/2 compared to 72 h. a 15 isolates from Southeast Asia with varying PC1/2 were assayed using the eRRSA. 72 h post-drug treatment samples were measured to give a fold change for each isolate and those fold changes were correlated with each isolate’s PC1/2 (Spearman r = − 0.6071). Isolates with red boxes are kelch13 mutants and the 95% confidence interval around the best-fit line (\(y\, = \, - 6.025x\, + \,61.14\)) is denoted with dotted lines. b The same 15 isolates were assayed using the eRRSA and 120 h post-drug treatment samples were measured to calculate a fold change for each isolate. The fold changes were correlated with PC1/2 (isolates marked with red boxes are kelch13 mutants and the 95% confidence interval of the best-fit line is denoted with dotted lines) (Spearman r = − 0.8393); the 120 h eRRSA samples showed an increased correlation with PC1/2 compared to the 72 h samples

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