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Table 1 The main pharmacokinetic parameters (mean ± SD) of naphthoquine (NQ) in male and female rats (n = 7 for each group) after a single oral administration of NQ (40 mg/kg)

From: The gender-related variability in the pharmacokinetics and antiplasmodial activity of naphthoquine in rodents

ParametersMaleFemale
AUC0–t (μg h/mL)36.12 ± 11.2532.82 ± 6.65
AUC0–∞ (μg h/mL)37.44 ± 11.8332.70 ± 7.06
Cmax (ng/mL)504.1 ± 206.6438.1 ± 114.5
Tmax (h)5.4 (2.0–12.0)3.1 (2.0–6.0)
t1/2 (h)192.1 ± 41.2143.9 ± 27.1*
MRT (h)162.6 ± 47.7173.1 ± 26.9
CL/F (L/h/kg)1.22 ± 0.451.27 ± 0.27
Vz (L/kg)316.7 ± 109.1285.4 ± 104.8
  1. * P < 0.05 (vs. male rats)