Table 1 The main pharmacokinetic parameters (mean ± SD) of naphthoquine (NQ) in male and female rats (n = 7 for each group) after a single oral administration of NQ (40 mg/kg)

AUC_0–t (μg h/mL)

36.12 ± 11.25

32.82 ± 6.65

AUC_0–∞ (μg h/mL)

37.44 ± 11.83

32.70 ± 7.06

C_max (ng/mL)

504.1 ± 206.6

438.1 ± 114.5

T_max (h)

5.4 (2.0–12.0)

3.1 (2.0–6.0)

t_1/2 (h)

192.1 ± 41.2

143.9 ± 27.1*

MRT (h)

162.6 ± 47.7

173.1 ± 26.9

CL/F (L/h/kg)

1.22 ± 0.45

1.27 ± 0.27

Vz (L/kg)

316.7 ± 109.1

285.4 ± 104.8