Table 3 Summary of Caco-2 and passive permeability (PAMPA) of SJ733 and SJ311
From: Selecting an anti-malarial clinical candidate from two potent dihydroisoquinolones
Method | pH | Permeability (10–6 cm/s) | |
|---|---|---|---|
(r)-SJ733 | (r)-SJ311 | ||
PAMPA | 3 | 66 ± 3.5 | 17 ± 2.3 |
5 | 380 ± 7.2 | 15 ± 6.7 | |
7.4 | 350 ± 130 | 9.4 ± 7.0 | |
Caco-2 | Apical to Basal | 9.4 ± 1.6 | 12.5 ± 0.7 |
Basolateral to Apical | 11.0 ± 1.6 | 16.6 ± 2.0 | |
Efflux Ratio | 1.17 ± 0.04 | 1.34 ± 0.21 | |