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Table 3 Summary of Caco-2 and passive permeability (PAMPA) of SJ733 and SJ311

From: Selecting an anti-malarial clinical candidate from two potent dihydroisoquinolones

Method pH Permeability (10–6 cm/s)
(r)-SJ733 (r)-SJ311
PAMPA 3 66 ± 3.5 17 ± 2.3
5 380 ± 7.2 15 ± 6.7
7.4 350 ± 130 9.4 ± 7.0
Caco-2 Apical to Basal 9.4 ± 1.6 12.5 ± 0.7
Basolateral to Apical 11.0 ± 1.6 16.6 ± 2.0
Efflux Ratio 1.17 ± 0.04 1.34 ± 0.21
  1. Data are shown as mean ± SD (n = 3)
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