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Table 1 CYP2C8 genotype and allele frequencies in Zanzibar

From: Influence of cytochrome P450 (CYP) 2C8 polymorphisms on the efficacy and tolerability of artesunate‐amodiaquine treatment of uncomplicated Plasmodium falciparum malaria in Zanzibar

Relative and (absolute) CYP2C8 genotype frequencies

Relative and (absolute) CYP2C8 allele frequencies

2C8*1/2C8*1

0.634 (392)

2C8*1

0.798 (987)

2C8*2/2C8*2

0.024 (15)

2C8*2

0.175 (216)

2C8*3/2C8*3

0.005 (3)

2C8*3

0.027 (33)

2C8*1/2C8*2

0.293 (181)

  

2C8*1/2C8*3

0.036 (22)

  

2C8*2/2C8*3

0.008 (5)

  
  1. Relative and absolute (n) frequencies among 618 children under 5 years old with uncomplicated falciparum malaria. The 2C8*2/2C8*3 genotype are individuals (n=5) that were heterozygous carriers for both CYP2C8*2 and CYP2C8*3. For these, 5 alleles were attributed each to the 2C8*2 and 2C8*3 allele frequencies
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Malaria Journal

ISSN: 1475-2875

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