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Fig. 2 | Malaria Journal

Fig. 2

From: Diversity-oriented synthesis derived indole based spiro and fused small molecules kills artemisinin-resistant Plasmodium falciparum

Fig. 2

Compounds 2 and 3 inhibit artemisinin-resistant parasite growth. a Synchronized ring-stage culture of artemisinin-sensitive (3D7) and artemisinin-resistant (R539T) parasites at 1% parasitaemia were treated with DMSO or different concentrations of artemisinin for 48 h. Giemsa-stained slides of treated culture were analysed to determine the parasitaemia at 0 and 48 h post-treatment. b Ring-stage synchronized culture of P. falciparum 3D7 and R539T strains were treated either with DMSO or compounds 2 or 3 at different concentrations for 48 h. Parasitaemia was calculated by examining Giemsa-stained slides prepared at 0 and 48 h post-treatment. c Graphs were plotted for percentage inhibition in parasitaemia at 48 h for different concentration and IC50 value was calculated for both compounds in artemisinin-sensitive (3D7) and artemisinin-resistant strains (R539T)

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