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Fig. 1 | Malaria Journal

Fig. 1

From: Diversity of KIR genes and their HLA-C ligands in Ugandan populations with historically varied malaria transmission intensity

Fig. 1

KIR haplotypes. KIR A haplotypes (a, b) are present in all populations worldwide. KIR A haplotype is composed of mainly inhibitory KIR except KIR2DS4. Allelic polymorphism is very high in the KIR A haplotype (KIR3DL1, 3DL2 and 3DL3 exhibit > 100 alleles, and 2DL1 and 2DL3 exhibit ~ 50 alleles). Haplotypes (b) has several activating receptors, with variable number of genes and fewer allelic polymorphisms. Some KIR B haplotypes are composed of combinations of haplotypes (a, b) (CenA-TelB, CenB-TelA). The HLA epitopes bound by some KIRs are known and are indicated as C1, C2 or Bw4

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Malaria Journal

ISSN: 1475-2875

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