Diversity of KIR genes and their HLA-C ligands in Ugandan populations with historically varied malaria transmission intensity

Table 5 Comparative prevalence of KIR and HLA-C genetic variants from 3 sites of Uganda with historically varied malaria transmission intensity

	Tororo, N = 356		Jinja, N = 168		Kanungu, N = 405		p-values
	n	(%)	n	(%)	n	(%)	T vs J	T vs K	J vs K
HLA-C
C1C1	66	18.5%	39	23.2%	75	18.5%	0.285	0.296	0.043
C1C2	195	54.8%	93	55.4%	202	49.9%
C2C2	95	26.7%	36	21.4%	128	31.6%

	Tororo, N = 120		Jinja, N = 59		Kanungu, N = 161		p-values
	n	(%)	n	(%)	n	(%)	T vs J	T vs K	J vs K
KIRAA/HLA-C
AA/C1C1	21	17.5%	11	18.6%	22	13.7%	0.213	0.537	0.282
AA/C1C2	62	51.7%	37	62.8%	93	57.8%
AA/C2C2	37	30.8%	11	18.6%	46	28.5%

	Tororo, N = 193		Jinja, N = 93		Kanungu, N = 232		p-values
	n	(%)	n	(%)	n	(%)	T vs J	T vs K	J vs K
KIRBX/HLA-C
BX/C1C1	36	18.6%	23	24.7%	50	21.5%	0.424	0.062	0.424
BX/C1C2	109	56.5%	46	49.5%	105	45.3%
BX/C2C2	48	24.9%	24	25.8%	77	33.2%

	Tororo, N = 438		Jinja, N = 414		Kanungu, N = 446		p-values
	n	(%)	n	(%)	n	(%)	T vs J	T vs K	J vs K
Centromeric KIR motif
CenAA	191	43.6%	171	41.3%	190	42.6%	0.478	0.552	0.928
CenAB	175	40.0%	182	44.0%	192	43.0%
CenBB	72	16.4%	61	14.7%	64	14.4%

	Tororo, N = 438		Jinja, N = 413		Kanungu, N = 446		p-values
	n	(%)	n	(%)	n	(%)	T vs J	T vs K	J vs K
Telomeric KIR Motif
TelAA	314	71.7%	283	68.5%	326	73.1%	0.141	0.088	0.061
TelAB	115	26.3%	112	27.1%	113	25.3%
TelBB	9	2.0%	18	4.4%	7	1.6%

p-values for comparisons of the prevalence of KIR AA vs BX genotypes, HLA (C1C1) vs C1C2 vs C2C2, KIR/HLA (AA/C1C1) vs AA/C1C2 vs AA/C2C2, KIR/HLA (BX/C1C1) vs BX/C1C2 vs BX/C2C2, centromeric (CenAA) vs CenAB vs CenBB, telomeric (TelAA) vs TelAB vs TelBB in Tororo (T), Jinja (J) and Kanungu (K) districts were determined using Fisher’s exact test.

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