|
Region
|
Mutations
|
Frequency in global
|
Frequency in Bioko
|
Distribution (Africa%/Asia%)
|
Polyphen score
|
ΔΔG
|
|---|
|
A-Domain
|
E 46Q
|
24%
|
32%
|
75/25
|
0.893*
|
− 0.211536
|
|
E 46R
|
0%(7/1406)
|
0%
|
100/0
|
0.732*
|
0.0221299
|
|
L 49 V
|
1%
|
3%
|
100/0
|
0.944*
|
1.12894
|
|
I116S
|
13%
|
19%
|
99/1
|
0.924*
|
0.342025
|
|
I116T
|
0%(2/1406)
|
0%
|
100/0
|
0.965**
|
− 0.386652
|
|
K119R
|
13%
|
16%
|
52/48
|
0.020
|
− 0.194173
|
|
L122I
|
2%
|
7%
|
100/0
|
0.965**
|
0.571158
|
|
S123N
|
19%
|
7%
|
57/43
|
0.000
|
− 0.26044
|
|
S123R
|
0%(2/1406)
|
0%
|
50/50
|
0.184
|
− 0.349001
|
|
Y128F
|
21%
|
28%
|
98/2
|
0.965**
|
0.770957
|
|
K130R
|
93%
|
94%
|
49/51
|
0
|
0.0703724
|
|
T134S
|
37%
|
24%
|
43/57
|
0.463*
|
0.705496
|
|
TSR
|
A219E
|
2%
|
0%
|
8/92
|
0.122
|
− 0.166547
|
|
A219T
|
2%
|
8%
|
87/13
|
0.954*
|
− 0.345222
|
|
E221A
|
0%(6/1406)
|
1%
|
100/0
|
0.924*
|
0.128533
|
|
G228V
|
3%
|
3%
|
100/0
|
0.997**
|
0.411189
|
|
DIV
|
R285G
|
1%
|
0%
|
100/0
|
0.663*
|
1.3286
|
|
R285S
|
1%
|
0%
|
100/0
|
0.663*
|
1.16481
|
|
L287P
|
97%
|
95%
|
51/49
|
0.000
|
0.546262
|
|
R290W
|
29%
|
61%
|
72/28
|
0.001
|
0.336084
|
|
D297H
|
54%
|
29%
|
47/53
|
0.000
|
− 0.336216
|
|
D297E
|
5%
|
8%
|
92/8
|
0.000
|
− 0.352555
|
|
D297Q
|
9%
|
14%
|
25/75
|
0.000
|
− 0.524996
|
|
E298D
|
2%
|
0%
|
100/0
|
0.544*
|
− 0.0333006
|
|
E298K
|
0%(4/1406)
|
0%
|
100/0
|
0.893*
|
− 1.10525
|
|
P299S
|
1%
|
5%
|
100/0
|
0.958**
|
1.17995
|
|
S419P
|
96%
|
90%
|
51/49
|
0.000
|
− 0.8004
|
|
K421N
|
29%
|
41%
|
90/10
|
0.051
|
1.41483
|
|
V422I
|
0%(3/1406)
|
2%
|
100/0
|
0.455*
|
− 0.147794
|
|
TM (DV)
|
Y526F
|
4%
|
0%
|
0/100
|
0.051
|
0.56536
|
- Polyphen score with * indicated possibly damaging mutation; Polyphen score with ** indicated probably damaging mutation. Polyphen score without * indicated benign mutation
