Skip to main content

Table 4 Information of mutations at T cell epitopes and mutation effect prediction

From: Genetic diversity and natural selection on the thrombospondin-related adhesive protein (TRAP) gene of Plasmodium falciparum on Bioko Island, Equatorial Guinea and global comparative analysis

Region Mutations Frequency in global Frequency in Bioko Distribution (Africa%/Asia%) Polyphen score ΔΔG
A-Domain E 46Q 24% 32% 75/25 0.893* − 0.211536
E 46R 0%(7/1406) 0% 100/0 0.732* 0.0221299
L 49 V 1% 3% 100/0 0.944* 1.12894
I116S 13% 19% 99/1 0.924* 0.342025
I116T 0%(2/1406) 0% 100/0 0.965** − 0.386652
K119R 13% 16% 52/48 0.020 − 0.194173
L122I 2% 7% 100/0 0.965** 0.571158
S123N 19% 7% 57/43 0.000 − 0.26044
S123R 0%(2/1406) 0% 50/50 0.184 − 0.349001
Y128F 21% 28% 98/2 0.965** 0.770957
K130R 93% 94% 49/51 0 0.0703724
T134S 37% 24% 43/57 0.463* 0.705496
TSR A219E 2% 0% 8/92 0.122 − 0.166547
A219T 2% 8% 87/13 0.954* − 0.345222
E221A 0%(6/1406) 1% 100/0 0.924* 0.128533
G228V 3% 3% 100/0 0.997** 0.411189
DIV R285G 1% 0% 100/0 0.663* 1.3286
R285S 1% 0% 100/0 0.663* 1.16481
L287P 97% 95% 51/49 0.000 0.546262
R290W 29% 61% 72/28 0.001 0.336084
D297H 54% 29% 47/53 0.000 − 0.336216
D297E 5% 8% 92/8 0.000 − 0.352555
D297Q 9% 14% 25/75 0.000 − 0.524996
E298D 2% 0% 100/0 0.544* − 0.0333006
E298K 0%(4/1406) 0% 100/0 0.893* − 1.10525
P299S 1% 5% 100/0 0.958** 1.17995
S419P 96% 90% 51/49 0.000 − 0.8004
K421N 29% 41% 90/10 0.051 1.41483
V422I 0%(3/1406) 2% 100/0 0.455* − 0.147794
TM (DV) Y526F 4% 0% 0/100 0.051 0.56536
  1. Polyphen score with * indicated possibly damaging mutation; Polyphen score with ** indicated probably damaging mutation. Polyphen score without * indicated benign mutation