Baseline incidence of meningitis, malaria, mortality and other health outcomes in infants and young sub-Saharan African children prior to the introduction of the RTS,S/AS01E malaria vaccine

doi:10.1186/s12936-021-03670-w

Table 6 All-cause mortality rate per 100,000 person-years by gender

From: Baseline incidence of meningitis, malaria, mortality and other health outcomes in infants and young sub-Saharan African children prior to the introduction of the RTS,S/AS01_E malaria vaccine

	Kombewa, Kenya			Kintampo, Ghana			Navrongo, Ghana			Overall
	n	PY	Value (95% CI)	n	PY	Value (95% CI)	n	PY	Value (95% CI)	n	PY	Value (95% CI)
Female	N = 1018			N = 1786			N = 584			N = 3388
All causes	7	600	1166 (469, 2402)	12	1154	1040 (537, 1817)	1	374	267 (7, 1488)	20	2129	940 (574, 1451)
AESI	0	600	0 (0, 614)	0	1154	0 (0, 320)	0	374	0 (0, 985)	0	2129	0 (0, 173)
Meningitis	0	600	0 (0, 614)	0	1154	0 (0, 320)	0	374	0 (0, 985)	0	2129	0 (0, 173)
Malaria	0	600	0 (0, 614)	6	1154	520 (191, 1132)	0	374	0 (0, 985)	6	2129	282 (103, 614)
P. falciparum	0	600	0 (0, 614)	1	1154	87 (2, 483)	0	374	0 (0, 985)	1	2129	47 (1, 262)
Other AEs	7	600	1166 (469, 2402)	6	1154	520 (191, 1132)	1	374	267 (7, 1488)	14	2129	658 (360, 1104)
Male	N = 1093			N = 1817			N = 599			N = 3509
All causes	14	649	2157 (1179, 3620)	7	1176	595 (239, 1227)	1	379	264 (7, 1469)	22	2204	998 (626, 1511)
AESI	0	649	0 (0, 568)	0	1176	0 (0, 314)	0	379	0 (0, 973)	0	2204	0 (0, 167)
Meningitis	0	649	0 (0, 568)	0	1176	0 (0, 314)	0	379	0 (0, 973)	0	2204	0 (0, 167)
Malaria	3	649	462 (95, 1351)	1	1176	85 (2, 474)	0	379	0 (0, 973)	4	2204	182 (49, 465)
P. falciparum	2	649	308 (37, 1113)	1	1176	85 (2, 474)	0	379	0 (0, 973)	3	2204	136 (28, 398)
Other AEs	11	649	1695 (846, 3033)	6	1176	510 (187, 1111)	1	379	264 (7, 1469)	18	2204	817 (484, 1291)
Total	N = 2111			N = 3603			N = 1183			N = 6897
All causes	21	1249	1681 (1041, 2569)	19	2330	816 (491, 1274)	2	754	265 (32, 959)	42	4332	969 (699, 1310)
AESI	0	1249	0 (0, 295)	0	2330	0 (0, 158)	0	754	0 (0, 490)	0	4332	0 (0, 85)
Meningitis	0	1249	0 (0, 295)	0	2330	0 (0, 158)	0	754	0 (0, 490)	0	4332	0 (0, 85)
Malaria	3	1249	240 (50, 702)	7	2330	300 (121, 619)	0	754	0 (0, 490)	10	4332	231 (111, 424)
P. falciparum	2	1249	160 (19, 578)	2	2330	86 (10, 310)	0	754	0 (0, 490)	4	4332	92 (25, 236)
Other AEs	18	1249	1441 (854, 2277)	12	2330	515 (266, 900)	2	754	265 (32, 959)	32	4332	739 (505, 1043)

According-to-protocol cohort, 5 to 17 months age-group N, Number of study participants at risk during a follow-up period of approximately 6 months after each dose of the virtual primary vaccination schedule censored at the next dose; n, number of cases reported during that follow-up period
CI: confidence interval; PY: person-years; AE: adverse event; AESI: adverse event of special interest

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