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Fig. 22 | Malaria Journal

Fig. 22

From: Systematic identification of plausible pathways to potential harm via problem formulation for investigational releases of a population suppression gene drive to control the human malaria vector Anopheles gambiae in West Africa

Fig. 22

Pathway 20 Human health: Potentially increased vector competence in dsxFCRISPRh transgenics could increase disease transmission in humans. While increased vector competence (bc) would lead to increases in vectorial capacity, the net effect of a population suppression gene drive could ultimately reduce the impact of this potential harm by reducing the density of mosquitoes (A), including transgenic ones. Alternatively, vector competence could increase as a result of decreased densities of An. gambiae [149, 150], which would be assessed via the modelling outlined in steps two and four of the analysis plan. The components of vectorial capacity (V) that would be affected in this pathway are shown in red in the equation

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