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Fig. 25 | Malaria Journal

Fig. 25

From: Systematic identification of plausible pathways to potential harm via problem formulation for investigational releases of a population suppression gene drive to control the human malaria vector Anopheles gambiae in West Africa

Fig. 25

Pathway 23 Human health: Potentially altered physiology in dsxFCRISPRh transgenics could increase disease transmission in humans. This pathway is about the efficiency of disease transmission, so any altered physiological characteristics in the transgenics compared to the non-transgenic, such as immune system function or capacity for co-infection or extrinsic incubation period [151], might increase the transmission rate of a given pathogen. The net effect of a population suppression gene drive would ultimately reduce the impact of this potential harm by reducing the density of mosquitoes, including transgenic ones. The components of vectorial capacity (V) that would be affected in this pathway are shown in red in the equation

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