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Table 1 2 × 2 factorial design of parent trial

From: Community acceptance of reactive focal mass drug administration and reactive focal vector control using indoor residual spraying, a mixed‐methods study in Zambezi region, Namibia

  Human intervention
RACD*
(reactive case detection)
28 clusters
rfMDA
(reactive focal mass drug administration)
28 clusters
Mosquito intervention
No RAVC A B
(no reactive focal vector control) RACD only arm rfMDA only arm
28 clusters 14 clusters 14 clusters
RAVC C D
(reactive focal vector control) RACD + RAVC arm rfMDA + RAVC arm
28 clusters 14 clusters 14 clusters
  1. *RACD (reactive case detection): administering rapid diagnostic tests to people living within a 500 m radius of an index case; treating positives with artemether-lumefantrine and single dose primaquine
  2. rfMDA (reactive focal mass drug administration): presumptively treating individuals living within a 500 m radius around an index case using artemether-lumefantrine, without testing
  3. RAVC (reactive focal vector control): spraying long-acting insecticide, pirimiphos-methyl, on interior walls of sleeping structures in a 7-household radius around an index case